Jahr 2020
Evaluation of semi-supervised learning using sparse labeling to segment cell nuclei
Journal: Current Directions in Biomedical Engineering, doi.org/10.1515/cdbme-2020-3103
R. Bruch1, R. Rudolf1, R. Mikut2, M. Reischl2
1Institute of Molecularand Cell Biology, Faculty of Biotechnology, Mannheim University ofApplied Sciences, Mannheim, Germany
2Institute for Automation and AppliedInformatics, Karlsruhe Institute of Technology, Karlsruhe, Germany
Recent developments of novel matrices and on-tissue chemical derivatization reagents for MALDI-MSI
Journal: Analytical and Bioanalytical Chemistry, doi: 10.1007/s00216-020-03023-7
Q. Zho1, A. Fülöp1, C. Hopf1
1Zentrum für Massenspektrometrie und optische Spektroskopie (CeMOS), Fachhochschule Mannheim, Paul-Wittsack-Str. 10, 68163, Mannheim, Deutschland
Comparision of PLSR, MCR-ALS and Kernel-PLSR for the quantification of allergenic fragrance compounds in complex cosmetic products based on nonlinear 2D GC-IMS data
Journal: Chemometrics and Intelligent Laboratory Systems, doi: 10.1016 / j.chemolab.2020.104128
R. Brendel1,*, S. Schwolow1, S. Rohn2, P. Weller1
1Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163, Mannheim, Germany
2Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, 20146, Hamburg, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images
Journal: Analytical Chemistry 2020, doi: 10.1021 / acs.analchem.0c02585
T. Enzlein1,*, J. Cordes1,*, B. Munteanu1, W. Michno2, L. Serneels3, B. De Strooper3, J. Hanrieder4, I. Wolf5, L. Chávez-Gutiérrez3, C. Hopf1
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany
2Klinik für Psychiatrie und Neurochemie, Sahlgrenska-Akademie an der Universität Göteborg, Mölndal-Krankenhaus, Haus V3, Mölndal 43180, Schweden
3KU Leuven-VIB-Zentrum für Hirn- und Krankheitsforschung, VIB, Leuven 3000, Belgien ; Klinik für Neurowissenschaften, Leuven Institut für Neurowissenschaften und Krankheiten, KU Leuven, Leuven 3000, Belgien ; UK Dementia Research Institute an der UCL, University College London, London WC1E 6BT UK
4Klinik für Psychiatrie und Neurochemie, Sahlgrenska-Akademie der Universität Göteborg, Krankenhaus Mölndal, Haus V3, Mölndal 43180, Schweden ; Abteilung für neurodegenerative Erkrankungen, University College London Queen Square Institut für Neurologie, Queen Square, London WC1N 3BG, Vereinigtes Königreich
5Fakultät für Informatik, Fachhochschule Mannheim, Paul-Wittsack-Straße 10, Mannheim 68163
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Spatially resolved mass spectrometry analysis of amyloid plaque-associated lipids
Journal: Journal of Neurochemistry, doi: 10.1111 / jnc.15216
M. Blank2, C. Hopf1
1Zentrum für Massenspektrometrie und optische Spektroskopie (CeMOS), Fachhochschule Mannheim, Paul-Wittsack-Str. 10, 68163, Mannheim, Deutschland.
2Center for Struktural Molecular (CEBIME/PROPESQ), Federal University of Santa Catarina, Florianopolis, Brazil.
An alternative pathway for sweet sensation: possible mechanisms and physiological relevance
Journal: European Journal of Physiology, doi:10.1007/s00424-020-02467-1
E. von Molitor1,*, K. Riedel2, M. Krohn2, R. Rudolf1,3, M. Hafner1, T. Cesetti1
1Institut für Molekular- und Zellbiologie, Hochschule Mannheim, 68163, Mannheim
2BRAIN AG, 64673, Zwingenberg, Deutschland
3Interdisziplinäres Zentrum für Neurowissenschaften, Universität Heidelberg, 69120, Heidelberg
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Feasibility Study for a Chemical Process Particle Size Characterization System for Explosive Environments Using Low Laser Power
Journal: Micromachines, doi:10.3390/mi11100911
J. Ross-Jones1,2, T. Teumer1,2, S. Wunsch1, L. Petri1, H. Nirschl2, M.J. Krause2, F.-J. Methner3, M. Rädle1
1Zentrum für Massenspektrometrie und optische Spektroskopie, Fachhochschule Mannheim, Paul-Wittsack-Straße 10, 68163 Mannheim.
2Forschungsgruppe Gitter Boltzmann, Institut für Maschinenbau, Verfahrenstechnik und Mechanik, Karlsruher Institut für Technologie, Straße am Forum 8, 76131 Karlsruhe.
3Lehrstuhl für Brauwissenschaft, Institut für Lebensmitteltechnologie und Lebensmittelchemie, Technische Universität Berlin, Seestraße 13, 13353 Berlin.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Self-optimization of organic syntheses in an automated-flow microreactor system using Simplex and DoE
Journal: Chemie Ingenieur Technik, doi: 10.1002/cite.202055124
V. Fath1,*, P. Lau2, C. Greve2, N. Kockmann3
1Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
2Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt/Germany
3Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Kinetic measurements of acrylic acid polymerization in a pendular slug reactor
Journal: Chemie Ingenieur Technik, doi: 10.1002 / cite.202055217
T. Klement1,*, T. Röder1, N. Kockmann2
1Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
2Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
A Scaffold-Free 3-D Co-Culture Mimics the Major Features of the Reverse Warburg Effect In Vitro
Journal: Cells, doi: 0.3390/cells9081900
F. Keller1,2,*, R. Bruch, R. Schneider3, J. Meier-Hubberten3, M. Hafner1,2, R. Rudolf1,2
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Institute of Medical Technology, Medical Faculty Mannheim of Heidelberg University and Mannheim University of Applied Sciences, 68167 Mannheim, Germany
3TIP Oncology, Merck Healthcare KGaA, 64289 Darmstadt, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Gas-phase volatilomic approaches for quality control of brewing hops based on simultaneous GC-MS-IMS and machine learning
Journal: Analytical and Bioanalytical Chemistry, doi: 10.1007 / s00216-020-02842-y
R. Brendel1,*, S. Schwolow1, S. Rohn2, P. Weller1
1Paul-Wittsack-Straße 10, 68163, Mannheim
2Institut für Lebensmittelchemie, Hamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146, Hamburg
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs.
Journal: Analytical Chemistry, https://doi.org/10.1021/acs.analchem.0c02186
M. S. Unger1,2,3,*, L. Schumacher1, T. Enzlein1, D. Weigt1, M.J. Zamek-Gliszczynski4, M. Schwab5,6,7, A.T. Nies5,6, G. Drewes3, S. Schulz1, F.B.M. Reinhard3, C. Hopf1,2,*
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany
2Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
3Cellzome – a GlaxoSmithKline company, Meyerhofstr. 1, 69177 Heidelberg, Germany
4Drug Metabolismand Pharmacokinetics, GlaxoSmithKline, 1250 S Collegeville Rd, Collefeville, Pennsylvania 19426, United States
5Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany
6iFit Cluster of Excellence (EXC2180) “Image Guided and Functionally Instructed Tumor Therapies”, University of Tübingen, Tübingen, Germany
7Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tübingen, Geschwister Scholl Platz, 72074 Tübingen, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Recent Advances in Experimental Techniques for Flow and Mass Transfer Analyses in Thermal Separation Systems
Journal: Chemie Ingenieur Technik, doi: https://doi.org/10.1002/cite.202000076
U. Hampel1,2, M. Schubert1, A. Döß1, J. Sohr, V. Vishwakarma1, J.-U. Repke3, S.J. Gerke3, H. Leuner3, M. Rädle4, V. Kapoustina4, L. Schmitt4, M. Grünewald5, J.H. Brinkmann5, D. Plate5, E.Y. Kenig6, N. Lutters6, L. Bolenz6, F. Buckmann, D. Toye7, W. Arlt8, T. Linder8, R. Hoffmann9, H. Klein10, S. Rehfeldt10, T. Winkler10, H.-J. Bart11, D. Wirz11, J. Schulz11, S. Scholl12, W. Augustin12, K. Jasch12, F. Schlüter12, N. Schwerdtfeger12, S. Jahnke12, A. Jupke13, C. Kabatnik13, A.S. Braeuer14, M. D‘Auria14, T. Runowski15, M.F. Casal15, K. Becker15, A.-L. David15, A. Górak16, M. Skiborowski16, K. Groß16, H. Qammar16
1Helmholtz-Zentrum Dresden-Rossendorf, Institut für Fluiddynamik, Bautzner Landstraße 400, 01328 Dresden, Germany.
2Technische Universität Dresden, Institut für Energietechnik, 01062 Dresden, Germany.
3Technische Universität Berlin, Institut für Prozess- und Verfahrenstechnik, Straße des 17. Juni 135, 10623 Berlin, Germany.
4Hochschule Mannheim, Center for Mass Spectrometry and Optical Spectroscopy, John-Deere-Straße 81A, 68163 Mannheim, Germany.
5Ruhr-Universita¨t Bochum, Lehrstuhl für Fluidverfahrenstechnik, Universitätsstraße 150, 44801 Bochum, Germany.
6Universität Paderborn, Fakultat für Maschinenbau, Lehrstuhl für Fluidverfahrenstechnik, Pohlweg 55, 33098 Paderborn, Germany.
7Universite de Liege, Department of Chemical Engineering, Alle edu six Aout, 17B, 4000 Liege 1, Belgium.
8Friedrich-Alexander-Universität Erlangen-Nurnberg, Institute of Separation Science and Technology, Egerlandstraße 3, 91058 Erlangen, Germany.
9Linde Aktiengesellschaft, Engineering Division, Dr.-Carl-von-Linde-Straße 6–14, 82049 Pullach bei München, Germany.
10Technical University of Munich, Department of Mechanical Engineering, Institute of Plant and Process Technology, Boltzmannstraße 15, 85748 Garching, Germany.
11Technische Universität Kaiserslautern, Lehrstuhl für Thermische Verfahrenstechnik, PF 3049, 67653 Kaiserslautern, Germany.
12Technische Universität Braunschweig, Institute for Chemical and Thermal Process Engineering, Langer Kamp 7, 38106 Braunschweig, Germany.
13RWTH Aachen University, Aachener Verfahrenstechnik, Fluidverfahrenstechnik, Forckenbeckstraße 51, 52074 Aachen, Germany.
14Technische Universita¨t Bergakademie Freiberg (TUBAF), Institute of Thermal-, Environmental and Resources’ Process Engineering (ITUN), Leipziger Straße 28, 09599 Freiberg, Germany.
15Bayer AG, Engineering & Technology, Thermal Separation Technologies, 51368 Leverkusen, Germany.
16TU Dortmund University, Department of Biochemical and Chemical Engineering, Laboratory of Fluid Separations, Emil-Figge-Straße 70, 44227 Dortmund, Germany.
Fast Quantification Without Conventional Chromatography, the Growing Power of Mass Spectrometry
Journal: Analytical Chemistry, doi: 10.1021/acs.analchem.0c00877
G. Gachumi1, R.W. Purves1,2, C. Hopf3, A. El-Aneed1
1College of Pharmacy and Nutrition, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada, S7N 5E5.
2Centre for Veterinary Drug Residues, Canadian Food Inspection Agency, 116 Veterinary Rd, Saskatoon, SK, Canada, S7N 2R3.
3Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Strasse 10, 68163 Mannheim, Germany.
Lab‐scale microreactor plant for the study of methylations with liquid chloromethane
Journal: Chemical Engineering Technology, doi.org/10.1002/ceat.202000011
M. Sc. C.V. Benzin1,2,*,Prof. Dr.-Ing. N. Kockmann1, Prof. Dr. T. Röder2
1TU Dortmund University, Laboratory of Equipment Design, Emil-Figge-Straße 68, 44227 Dortmund, Germany
2Hochschule Mannheim University of Applied Sciences, Institute of Chemical Process Engineering, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Self-optimising processes and real-timeoptimisation of organic syntheses in a microreactor system using Nelder–Mead and design of experiments
Journal: Reaction Chemistry & Engineering, doi: 10.1039/d0re00081g
V. Fath3,*, N. Kockmann1, J. Otto2, T. Röder3
1Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund, Germany
2Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
3Hochschule Mannheim University of Applied Sciences, Institute of Chemical Process Engineering, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Efficient Kinetic Data Acquisition and Model Prediction: Continuous Flow Microreactors, Inline FT-IR Spectroscopy, and Self-modeling Curve Resolution
Journal: Organic Process Research & Development, doi.org/10.1021/acs.oprd.0c00037
V. Fath1,2, *, P. Lau3, Chr. Greve3, N. Kockmann1, T. Röder2
1Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund/Germany
2Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
3Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt/Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
New Derivatization Reagent for Detection of free Thiol-groups in Metabolites and Proteins in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
Journal: Analytical Chemistry, doi.org/10.1021/acs.analchem.9b05630
A. Fülöp1, T. Bausbacher1, St. Rizzo2, Q. Zhou1, H. Gillandt2, C. Hopf1, M. Rittner2
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Sirius Fine Chemicals SiChem GmbH, 28359 Bremen, Germany
Molecule Sensitive Optical Imaging and Monitoring Techniques-A Review of Applications in Micro-Process Engineering.
Journal: Chemie Ingenieur Technik, doi:10.1002/cite.202000076
M. Nachtmann1, J. Deuerling1,*, M. Rädle1
1Forschungszentrum CeMOS, Fachhochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Deutschland
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Sensing Senses: Optical Biosensors to Study Gustation
Journal: Sensors (Basel), doi: https://doi.org/10.3390/s20071811
E. von Molitor1,*, K. Riedel2, M. Hafner1, R.Rudolf1,3, T. Cesetti1
1Institut für Molekular- und Zellbiologie, Hochschule Mannheim, 68163 Mannheim
2BRAIN AG, 64673 Zwingenberg
3Interdisziplinäres Zentrum für Neurowissenschaften, Universität Heidelberg, 69120 Heidelberg
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Routine Optical Clearing of 3D-Cell Cultures: Simplicity Forward
Journal: Frontiers in Molecular Biosiences, doi.org/10.3389/fmolb.2020.00020
E. Nürnberg1,2,*, M. Vitacolonna1, J. Klicks1,*, E. von Molitor1,*, T. Cesetti1, F. Keller1,*, R. Bruch1,*, T. Ertongur-Fauth3, K. Riedel3, P. Scholz3, T. Lau2, R. Schneider4, J. Meier4, M. Hafner1, R. Rudolf1
1Institut für Molekular- und Zellbiologie, Fakultät für Biotechnologie, Fachhochschule Mannheim, Mannheim
2Zentralinstitut für Seelische Gesundheit, Abteilung für translationale Hirnforschung, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim
3BRAIN AG, Zwingenberg
4TIPP Onkologie, Merck Healthcare KGaA, Darmstadt
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
A paper-based colorimetric sensor array for discrimination of monofloral European honeys based on gold nanoparticles and chemometrics data analysis
Journal: Molecular and Biomolecular Spectroscopy, https://doi.org/10.1016/j.saa.2020.119076
M. Chaharlangi1, J. Tashkhourian1, M. mahdi Bordbar1, R. Brendel2,*, P. Weller2, B. Hemmateenejad1,3
1Abteilung für Chemie, Universität Shiraz, Shiraz 71454, Iran
2Institut für Instrumentelle Analytik und Bioanalytik, Fachhochschule Mannheim, 68163 Mannheim
3Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Analysis of Calcium Signaling in Live Human Tongue Cell 3D-Cultures upon Tastant Perfusion
Journal: Cell Calcium, doi.org/10.1016/j.ceca.2020.102164
E. von Molitor 1,*, E. Nürnberg 1,*, T. Ertongur-Fauth 2, P. Scholz 2, K. Riedel 2, M. Hafner 1, R. Rudolf 1,3, T. Cesetti 1
1Institute of Molecular and Cell Biology, Hochschule Mannheim, 68163 Mannheim, Germany
2 BRAIN AG, 64673 Zwingenberg, Germany
3Interdisciplinary Center for Neurosciences, Heidelberg University, 69120 Heidelberg, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany