Jahr 2024

Autonomous Online Optimization in Flash Chemistry Using Online Mass Spectrometry

Journal: Organic Process Research & Development (2024), https://doi.org/10.1021/acs.oprd.3c00397, IF: 3,1

Claudio Lehmann1, Kevin Eckey2, Maria Viehoff2, Christoph Greve2, Thorsten Röder1

1Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany

2Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany

 

Mutation of the Plasmodium falciparum Flavokinase Confers Resistance to Roseoflavin and 8-Aminoriboflavin

Journal: ACS Infectious Diseases, https://doi.org/10.1021/acsinfecdis.4c00289, IF: 4,0

Ayman Hemasa1, Christina Spry1, Matthias Mack2, Kevin J. Saliba1

1Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia

2Institute for Technical Microbiology, Department of Biotechnology, Mannheim University of Applied Sciences, Mannheim 68163, Germany

 

Aberrant evoked calcium signaling and nAChR cluster morphology in a SOD1 D90A hiPSC-derived neuromuscular model

Journal: Frontiers in Cell and Developmental Biology, https://doi.org/10.3389/fcell.2024.1429759, IF: 5,5

Nathalie Couturier1,2, Sarah Janice Hörner1,2, Elina Nürnberg1, Claudio Joazeiro3, Mathias Hafner4,5, Rüdiger Rudolf1,2,4,5

1CeMOS, Mannheim University of Applied Sciences, Mannheim, Germany

2Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany

3Center for Molecular Biology, Heidelberg University, Heidelberg, Germany

4Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany

5Institute of Medical Technology, Mannheim University of Applied Sciences and Heidelberg University, Mannheim, Germany

 

Integrative Single-Plaque Analysis Reveals Signature Aβ and Lipid Profiles in the Alzheimer’s Brain

Journal: Analytical Chemistry, DOI: 10.1021/acs.analchem.3c05557, IF: 7,4

Thomas Enzlein1, 2, 3, Tammaryn Lashley4, Denis Abu Sammour1, Carsten Hopf1, 5, 6, Lucía Chávez-Gutiérrez2, 3

1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, Mannheim 68163, Germany.

2KU Leuven-VIB Center for Brain & Disease Research, VIB, Leuven 3000, Belgium.

3Department of Neurosciences, Leuven Institute for Neuroscience and Disease, KU Leuven, Leuven 3000, Belgium.

4Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, U.K.

5Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Heidelberg 69120, Germany.

6Medical Faculty, Heidelberg University, Heidelberg 69120, Germany.

 

Quantitative Analysis of Chlorogenic Acid during Coffee Roasting via Raman Spectroscopy

Journal: Chemosensorshttps://doi.org/10.3390/chemosensors12060106, IF: 4,2

Deborah Herdt1, Tobias Teumer2, Shaun Paul Keck3,† Thomas Kunz4, Victoria Schiwek4, Sarah Kühnemuth4, Frank-Jürgen Methner4, Matthias Rädle1

1CeMOS Research and Transfer Center, Mannheim University of Applied Sciences, 68163 Mannheim, Germany

2SAT Anlagentechnik GmbH, 25578 Daegeling, Germany

3Lummus Novolen Technology GmbH, 68165 Mannheim, Germany

4Institute of Food Technology and Food Chemistry, Department of Brewing and Beverage Technology, Technical University, 13355 Berlin, Germany

 

Gas chromatography ion mobility spectrometry (GC-IMS) dataset of honey samples with different botanical origins

Journal: Data in Brief, https://doi.org/10.1016/j.dib.2024.110532, IF: 1,2

Joscha Christmann1, 2, Sascha Rohn2, Philipp Weller1

1 Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.

2 Department of Food Chemistry and Analysis, Institute of Food, Technology and Food Chemistry, Technische Universität Berlin, TIB 4/3-1, Gustav-Meyer-Allee 25, 13355 Berlin, Germany.

Benchtop volatilomics supercharged: How machine learning based design of experiment helps optimizing untargeted GC-IMS gas phase metabolomics

Journal: Talanta, https://doi.org/10.1016/j.talanta.2024.125788, IF: 6,1

Hadi Parastar1,2, Philipp Weller1

1Department of Chemistry, Sharif University of Technology, P.O. Box 11155-9516, Tehran, Iran

2Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163, Mannheim, Germany

 

Isolation, characterisation and description of the roseoflavin producer Streptomyces berlinensis sp. nov.

Journal: Environmental Microbiology Reports, DOI: 10.1111/1758-2229.13266, IF: 4,06

Jimmy Jonathan Liunardo1, Sebastien Messerli1, Ann-Kathrin Gregotsch1, Sonja Lang1, Kerstin Schlosser1, Christian Rückert-Reed2, 3, Tobias Busche2, Jörn Kalinowski3, Martin Zischka4, Philipp Weller4, Imen Nouioui5, Meina Neumann-Schaal5, Chandra Risdian6, 7, Joachim Wink6, 8, Matthias Mack1

1Institute for Technical Microbiology, Department of Biotechnology, Mannheim University of Applied Sciences, Mannheim, Germany.

2Medical School East Westphalia-Lippe, Bielefeld University, Bielefeld, Germany.

3Technology Platform Genomics, Center for Biotechnology, Bielefeld University, Bielefeld, Germany.

4Institute for Instrumental Analytics and Bioanalytics, Department of Biotechnology, Mannheim University of Applied Sciences, Mannheim, Germany.

5Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.

6Department of Microbial Strain Collection, Helmholtz Centre for Infection Research, Braunschweig, Germany.

7Research Center for Applied Microbiology, National Research and Innovation Agency (BRIN), Bandung, Indonesia.

8German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig, Germany.

 

Investigation of interfacial mass transfer phenomena applying non-invasive Raman imaging and density gradient theory

Journal: Chemical Engineering Science, https://doi.org/10.1016/j.ces.2023.119672, IF: 4,9

J. Deuerling1, A. Alsalih1, R. Nagl2, T. Zeiner2, J.-U. Repke3, M. Rädle1

1Center for Mass Spectrometry and Optical Spectroscopy – CeMOS, University of Applied Sciences, Mannheim 68163, Germany

2Process Systems Engineering, Graz University of Technology, Graz 8010, Austria

3Process Dynamics and Operations Group – dbta, Technische Universität Berlin, Berlin 10623, Germany

 

 

Nontargeted Volatile Metabolite Screening and Microbial Contamination Detection in Fermentation Processes by Headspace GC-IMS

Journal: Anal. Chem, 10.1021/acs.analchem.3c04857, IF: 7,4

Joscha Christmann1, 2, Manuel Weber1, Sascha Rohn2, Philipp Weller1

1Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.

2Department of Food Chemistry and Analysis, Institute of Food Technology and Food Chemistry, Technische Universität Berlin, TIB 4/3-1, Gustav-Meyer-Allee 25, 13355 Berlin, Germany.

 

pyM2aia: Python interface for mass spectrometry imaging with focus on deep learning

Journal: Bioinformatics, https://doi.org/10.1093/bioinformatics/btae133, IF: 6,9

Jonas Cordes1,2, Thomas Enzlein3, Carsten Hopf2,3,4, Ivo Wolf1

1Faculty of Computer Science, Mannheim University of Applied Sciences, Mannheim 68163, Germany

2Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany

3Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, Mannheim, Germany

4Medical Faculty, Heidelberg University, Heidelberg 69120, Germany

 

Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction

Journal: Journal of Muscle Research and Cell Motility, https://doi.org/10.1007/s10974-024-09665-9, IF: 2,7

Rüdiger Rudolf1, 2 ,3, Isis C. Kettelhut4 and Luiz Carlos C. Navegantes5

1Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, 68163 Mannheim, Germany

2Interdisciplinary Center for Neurosciences, Heidelberg University, 69117 Heidelberg, Germany

3Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim Heidelberg University, 69167 Mannheim, Germany

4Department of Biochemistry & Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto-SP, 14049900 Brazil

5Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto-SP, 14049900 Brazil

Automated 2D peak detection in gas chromatography-ion mobility spectrometry through persistent homology

Journal: Analytica Chimica Acta, https://doi.org/10.1016/j.aca.2024.342204, IF: 6,9

Hadi Parastar1,2, Joscha Christmann2, Philipp Weller

1Department of Chemistry, Sharif University of Technology, P.O. Box 11155-9516, Tehran, Iran

2Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163, Mannheim, Germany

 

Surgical phase and instrument recognition: how to identify appropriate dataset splits

Journal: Int J CARS, https://doi.org/10.1007/s11548-024-03063-9, IF: 3,0

Georgii Kostiuchik1 ,2, Lalith Sharan3, 4, Benedikt Mayer5, Ivo Wolf6, Bernhard Preim5, Sandy Engelhardt3, 4

1 Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany. georgii.kostiuchik@med.uni-heidelberg.de

2 DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany. georgii.kostiuchik@med.uni-heidelberg.de

3 Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany

4 DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

5 Department of Simulation and Graphics, University of Magdeburg, Magdeburg, Germany

6 Department of Computer Science, Mannheim University of Applied Sciences, Mannheim, Germany

 

PerSurge (NOA-30) phase II trial of perampanel treatment around surgery in patients with progressive glioblastoma

Journal: BMC Cancer 24, https://doi.org/10.1186/s12885-024-11846-1, IF: 3,8

Sophie Heuer1, 2, Ina Burghaus3, Maria Gose3, Tobias Kessler1, 2, Felix Sahm4, 5, Philipp Vollmuth6, Varun Venkataramani1, 2, 7, Dirk Hoffmann1, 2, Matthias Schlesner8, 9, Miriam Ratliff2, 10, Carsten Hopf11, 12,13, Ulrich Herrlinger14, Franz Ricklefs15, Martin Bendszus6, Sandro M. Krieg16, Antje Wick1, Wolfgang Wick1, 2, Frank Winkler17, 18

1 Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.

2 Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

3 Coordination Centre for Clinical Trials (KKS) Heidelberg, 69120, Heidelberg, Germany.

4 Department of Neuropathology, University Hospital Heidelberg, INF 224, 69120, Heidelberg, Germany.

5 CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), Geman Cancer Research Center (DKFZ), Heidelberg, Germany.

6 Department of Neuroradiology, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.

7 Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.

8 German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

9 Biomedical Informatics, Data Mining and Data Analytics, University of Augsburg, Augsburg, Germany.

10 Neurosurgery Clinic, University Hospital Mannheim, 68167, Mannheim, Germany.

11 Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.

12 Medical Faculty, Heidelberg University, Heidelberg, Germany.

13 Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.

14 Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany.

15 Department of Neurosurgery, University Hospital Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

16 Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.

17 Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany. Frank.Winkler@med.uni-heidelberg.de.

18 Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. Frank.Winkler@med.uni-heidelberg.de.

 

High-Throughput Miniaturized Synthesis of PROTAC-Like Molecules

Journal: Small, https://doi.org/10.1002/smll.202307215, IF: 13,3

Ye Tian1, Maximilian Seifermann 1, Liana Bauer1, Charlotte Luchena1, Janne J. Wiedmann1, Stefan Schmidt2, Alexander Geisel2, Sergii Afonin3, Julius Höpfner1, Marius Brehm1, Xinyong Liu4, Carsten Hopf2, Anna A. Popova1, Pavel A. Levkin1

1Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

2Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), University of Applied Sciences Mannheim, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany

3Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany

4Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Wenhuaxi Road 44, Jinan, 250012 China

 

Myosin Va: Capturing cAMP for synaptic plasticity

Journal: Frontiers in Physiology, 10.3389/fphys.2023.1342994, IF: 4,0

Rüdiger Rudolf1,2,3

1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany

2Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany

3Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany