Year 2019

Towards optimized breast cancer 3D spheroid mono- and co-culture models for pharmacological research and screening (Kopie 1)

Journal of Cellular Biotechnolog, doi: 10.3233/JCB-199001

F. Keller1,*, R. Rudolf1,2, M. Hafner1,2

1Institute of Molecular and Cellular Biology, Mannheim University of Applied Sciences, Mannheim, Germany.

2Institute of Medical Technology of Heidelberg University and Mannheim University of Applied Sciences, Mannheim, Germany.

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany.

Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space (Kopie 1)

Journal: Molecular Pharmaceutics, doi.org/10.1021/acs.molpharmaceut.9b00897

M.S. Unger1,*, Matthias Schwab1,4,5, M.J. Zamek-Gliszczynski1, G. Drewes2, F.B.M. Reinhard2, C. Hopf3, J. Mudunuru3,4, A.T. Nies4

1Drug Metabolism and Disposition, GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States.

2Cellzome, a GlaxoSmithKline Company, 69117 Heidelberg, Germany.

3Center for Mass Spectrometry and Optical Spectroscopy (CeMOS) and Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, 68163 Mannheim, Germany.

4Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.

5Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tübingen, 72074 Tübingen, Germany.

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

Contrast enhancement of surface layers with fast middle-infrared scanning (Kopie 1)

Journal: Heliyon, doi: 10.1016/j.heliyon.2019.e02442

T. Kümmel1,3, T. Teumer1,2, P. Dörnhofer1, F.-J. Methner2, B. Wängler3, M. Rädle1

1Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, Mannheim, 68163, Germany

2Institute of Food Technology and Food Chemistry, Technische Universität Berlin, Seestraße 13, Berlin, 13353, Germany

3University of Heidelberg, Medical Faculty Mannheim, Theodor-Kutzer-Ufer 1-3, Mannheim, 68167, Germany

Model-based Scale-up Predictions: From Microto Millireactors using Inline FT-IR Spectroscopy (Kopie 1)

Journal: Organic Process Research & Development, doi.org/10.1021/acs.oprd.9b00265

V. Fath1,2,*, St. Szmais3, P. Lau3, N. Kockmann1, T. Röder2

1Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund, Germany

2Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany

3Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

Investigation of local layer thickness distributions in fluids with the help of near-infrared image analysis (Kopie 1)

Journal: Chemie Ingenieur Technik, doi: 10.1002/cite.201800106

I. Medina1, L. Schmitt1, V. Kapoustina1, M. Rädle1, St. Scholl2

1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences Paul-Wittsack Str. 10, 68163 Mannheim, Germany

2Technische Universita¨t Braunschweig, Institut für Chemische und Thermische Verfahrenstechnik, Langer Kamp 7, 38106 Braunschweig, Germany

Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors (Kopie 1)

Journal: Cell Chemical Biology, doi.org/10.1016/j.chembiol.2019.06.004

D. Weigt1,*, C. A.Parrish2, J. A.Krueger3, C. A.Oleykowski3, Al. R.Rendina4, C. Hopf1

1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim Technical University, Paul-Wittsack-Strasse 10, 68163 Mannheim, Germany

2Medicinal Chemistry, GlaxoSmithKline, 1250 S Collegeville Road, Collegeville, PA 19426, USA

3Immuno-Oncology and Combinations Research Unit, GlaxoSmithKline, 1250 S Collegeville Road, Collegeville, PA 19426, USA

4Screening, Profiling and Mechanistic Biology, GlaxoSmithKline, 1250 S Collegeville Road, Collegeville, PA 19426, USA

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

Data fusion of GC-IMS data and FT-MIR spectra for the authentication of olive oils and honeys—is it worth to go the extra mile? (Kopie 1)

Journal: Analytical and Bioanalytical Chemistry, doi: 10.1007/s00216-019-01978-w

S. Schwolow1, N. Gerhardt1, S. Rohn2, P. Weller1

1Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany

2Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, 20146 Hamburg, Germany

The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH) (Kopie 1)

Journal: Frotiers in Physiology, doi.org/10.3389/fphys.2019.00770

S. Schwolow1, N. Gerhardt1, S. Rohn2, P. Weller1, H. K. Drescher1, R. Weiskirchen2,  A. Fülöp3, C. Hopf3, E. González de San Román4, P. F. Huesgen4, A. de Bruin5, L. Bongiovanni5, A. Christ6,7, R. Tolba8, Ch. Trautwein1, D. C. Kroy1

1Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany

2Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital RWTH Aachen, Aachen, Germany

3Center for Biomedical Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany

4Central Institute for Engineering, Electronics and Analytics, ZEA-3 – Forschungszentrum Jülich, Jülich, Germany

5Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands

6Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany

7Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States

8Institute of Laboratory Animal Science and Experimental Surgery and Central Laboratory for Laboratory Animal Science, University Hospital RWTH Aachen, Aachen, Germany

In Situ Reaction Monitoring of Unstable Lithiated Intermediates through Inline FTIR Spectroscopy (Kopie 1)

Journal: Chemical Engineering Technology, doi.org/10.1002/ceat.201900074

Verena Fath1,*, Prof. Dr. Norbert Kockmann2, Prof. Dr. Röder1

1Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Strasse 10, 68163 Mannheim, Germany.

2Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Strasse 70, 44227 Dortmund, Germany.

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

Fast local Raman measurement to investigate concentration profiles during mixing processes in microchannels (Kopie 1)

Journal: Chemie Ingenieur Technik, doi.org/10.1002/cite.201800105

J. Deuerling1,*, St. Manser1,*, J. Siber1,*, Sh. Keck1,*, Th. M. Hufnagel1,*, L. Schmitt1,*, I. Medina1,*, Prof. Dr. Matthias Rädle1, Prof. Dr.-Ing. Jens-Uwe Repke2

1Hochschule Mannheim, CeMOS – Center for Mass Spectrometry and Optical Spectroscopy, Paul-Wittsack-Straße 10, 68163 Mannheim, Deutschland.

2 Technische Universitaät Berlin, Fachgebiet Dynamik und Betrieb technischer Anlagen, Straße des 17. Juni 135, 10623 Berlin, Deutschland.

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

A customized multispectral needle probe combined with a virtual photometric setup for in vivo detection of Lewis lung carcinoma in an animal model. Measurement Science and Technology (Kopie 1)

Journal: Measurement Science and Technology, doi.org/10.1088/1361-6501/ab24a1

F. Braun1,*, R. Schalk1,*, M. Nachtmann1,*, A. Hien1,*, R. Frank1,*, Th. Beuermann2, F.-J. Methner3, B. Kränzlin4, M. Rädle1,5, N. Gretz4,5

1Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany

2Institute for Process Control, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany

3Institute of Biotechnology, Technical University of Berlin, Chair of Brewing Science, Berlin, Germany

4Medical Research Center, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

Lattice-Boltzmann Simulation and Experimental Validation of a Microfluidic T-Junction for Slug Flow Generation (Kopie 1)

Journal: Chemical Engineering, doi.org/10.3390/chemengineering3020048

V. Paul Schulz1, N. Abbaspour1, T. Baumeister2 , T. Röder2

1Department of Mechanical Engineering, Cooperative State University Mannheim, Coblitzallee 1-9, 68163 Mannheim

2Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany; t.baumeister@mail.de (T.B.)

A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells (Kopie 1)

Journal: BMC Cancer, doi: 10.1186/s12885-019-5606-4

J. Klicks1,2,*, C. Maßlo3, A. Kluth4, R. Rudolf1,2, M. Hafner1,2

1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.

2Institute of Medical Technology, Mannheim University of Applied Sciences and Medical Faculty Mannheim of Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. 

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany

 

Quality assessment of olive oils based on temperature-ramped HS-GC-IMS and sensory evaluation: Comparison of different processing approaches by LDA, kNN, and SVM (Kopie 1)

Journal: Food Chemistry, doi: 10.1016/j.foodchem.2018.11.095

N. Gerhardt1, S. Schwolow1, S. Rohn2, P. RuizPérez-Cacho3, H. Galán-Soldevilla3, L. Arced4, P. Weller1

1Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, 68163 Mannheim, Germany

2Institute of Food Chemistry, Hamburg School of Food Science, University of Hamburg, 20146 Hamburg, Germany

3Laboratorio de Estudios Sensoriales (GrupoSens), Departamento de Bromatología y Tecnología de los Alimentos, Universidad de Córdoba. Campus de Rabanales, 14070 Córdoba, Spain

4Department of Analytical Chemistry, Institute of Fine Chemistry and Nanochemistry, University of Córdoba, Campus de Rabanales, Marie Curie Annex Building, 14071 Córdoba, Spain

Influence of a single microstructure on local mass transfer in liquid film flows (Kopie 1)

Journal: Chemical Engineering Research and Design, doi: 10.1016/j.cherd.2019.04.022

V. Kapoustina1, J. Guffart1, A. Hien1, J. Strischakov1, I. Medina1, M. Rädle1, J. Repke2

1Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, Mannheim, Germany.

2Chair of Process Dynamics and Operation, Technische Universität Berlin, Berlin, Germany.

A Novel Optical Tissue Clearing Protocol for Mouse Skeletal Muscle to Visualize Endplates in Their Tissue Context. (Kopie 1)

Journal: Frontiers in Cellular Neuroscience, doi.org/10.3389/fncel.2019.00049

M. P. I. Williams1,*, M. Rigon1,*, T. Straka1,2,*, S. J. Hörner1,2,*, M. Thiel3, N. Gretz4,5, M. Hafner1,5, M. Reischl6, R. Rudolf1,2,5,7

1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany

2Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany

3Department of Anesthesiology and Surgical Intensive Care Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

4Medical Faculty Mannheim, Medical Research Center, Heidelberg University, Mannheim, Germany

5Medical Faculty Mannheim, Institute of Medical Technology, Mannheim University of Applied Sciences, Mannheim, Germany

6Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany

7Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

 

 

Reactor Concept for Contactless Kinetic Measurement in Oscillating Droplets via Raman Spectroscopy (Kopie 1)

Journal: Chemie Ingenieur Technik, doi.org/10.1002/cite.201800199

T. Klement1,*, Prof. Dr. T. Röder1, Prof. Dr.-Ing. N. Kockmann2

1Mannheim University of Applied Sciences, Institute of Chemical Process Engineering, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.

2TU Dortmund University, Faculty of Biochemical and Chemical Engineering, Laboratory of Equipment Design, Emil-FiggeStraße 70, 44227 Dortmund, Germany

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

Bone Sialoprotein Shows Enhanced Expression in Early, High-Proliferation Stages of Three-Dimensional Spheroid Cell Cultures of Breast Cancer Cell Line MDA-MB-231. (Kopie 1)

Journal: Frontiers in Oncology, doi.org/10.3389/fonc.2019.00036

V. Rustamov1,2,*, F. Keller1,2,*, J. Klicks1,2,*, M. Hafner1,2, R. Rudolf1,2

1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany

2Institute of Medical Technology of Heidelberg University and Mannheim University of Applied Sciences, Mannheim, Germany

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development (Kopie 1)

Journal: Current Opinion in Biotechnolgy, doi: 10.1016/j.copbio.2018.08.003

S. Schulz1, M. Becker2, M.R. Groseclose3, S. Schadt4, C. Hopf1

1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany.

2Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach/Riss, Germany.

3Bioimaging US, GlaxoSmithKline, King of Prussia, PA 19406, United States.

4Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.

Model-based scale-up and reactor design for solvent-free synthesis of an ionic liquid in a millistructured flow reactor (Kopie 1)

Journal: Reaction Chemistry & Engineering, doi: 10.1039/c8re00148k

S. Schwolow1,*, B. Mutsch1,*, N. Kockmann2, T. Röder1  

1Mannheim University of Applied Sciences, Institute of Chemical Process Engineering, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany

2TU Dortmund University, Biochemical and Chemical Engineering, Equipment Design, Emil-Figge-Straße 68, 44227 Dortmund, Germany

*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany 

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