Overview Year 2017-2024
Autonomous Online Optimization in Flash Chemistry Using Online Mass Spectrometry
Journal: Organic Process Research & Development (2024), https://doi.org/10.1021/acs.oprd.3c00397, IF: 3,1
Claudio Lehmann1, Kevin Eckey2, Maria Viehoff2, Christoph Greve2, Thorsten Röder1
1Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
2Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany
Mutation of the Plasmodium falciparum Flavokinase Confers Resistance to Roseoflavin and 8-Aminoriboflavin
Journal: ACS Infectious Diseases, https://doi.org/10.1021/acsinfecdis.4c00289, IF: 4,0
Ayman Hemasa1, Christina Spry1, Matthias Mack2, Kevin J. Saliba1
1Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia
2Institute for Technical Microbiology, Department of Biotechnology, Mannheim University of Applied Sciences, Mannheim 68163, Germany
Aberrant evoked calcium signaling and nAChR cluster morphology in a SOD1 D90A hiPSC-derived neuromuscular model
Journal: Frontiers in Cell and Developmental Biology, https://doi.org/10.3389/fcell.2024.1429759, IF: 5,5
Nathalie Couturier1,2, Sarah Janice Hörner1,2, Elina Nürnberg1, Claudio Joazeiro3, Mathias Hafner4,5, Rüdiger Rudolf1,2,4,5
1CeMOS, Mannheim University of Applied Sciences, Mannheim, Germany
2Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany
3Center for Molecular Biology, Heidelberg University, Heidelberg, Germany
4Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany
5Institute of Medical Technology, Mannheim University of Applied Sciences and Heidelberg University, Mannheim, Germany
Integrative Single-Plaque Analysis Reveals Signature Aβ and Lipid Profiles in the Alzheimer’s Brain
Journal: Analytical Chemistry, DOI: 10.1021/acs.analchem.3c05557, IF: 7,4
Thomas Enzlein1, 2, 3, Tammaryn Lashley4, Denis Abu Sammour1, Carsten Hopf1, 5, 6, Lucía Chávez-Gutiérrez2, 3
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, Mannheim 68163, Germany.
2KU Leuven-VIB Center for Brain & Disease Research, VIB, Leuven 3000, Belgium.
3Department of Neurosciences, Leuven Institute for Neuroscience and Disease, KU Leuven, Leuven 3000, Belgium.
4Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, U.K.
5Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Heidelberg 69120, Germany.
6Medical Faculty, Heidelberg University, Heidelberg 69120, Germany.
Quantitative Analysis of Chlorogenic Acid during Coffee Roasting via Raman Spectroscopy
Journal: Chemosensors, https://doi.org/10.3390/chemosensors12060106, IF: 4,2
Deborah Herdt1, Tobias Teumer2, Shaun Paul Keck3,† Thomas Kunz4, Victoria Schiwek4, Sarah Kühnemuth4, Frank-Jürgen Methner4, Matthias Rädle1
1CeMOS Research and Transfer Center, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2SAT Anlagentechnik GmbH, 25578 Daegeling, Germany
3Lummus Novolen Technology GmbH, 68165 Mannheim, Germany
4Institute of Food Technology and Food Chemistry, Department of Brewing and Beverage Technology, Technical University, 13355 Berlin, Germany
Gas chromatography ion mobility spectrometry (GC-IMS) dataset of honey samples with different botanical origins
Journal: Data in Brief, https://doi.org/10.1016/j.dib.2024.110532, IF: 1,2
Joscha Christmann1, 2, Sascha Rohn2, Philipp Weller1
1 Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.
2 Department of Food Chemistry and Analysis, Institute of Food, Technology and Food Chemistry, Technische Universität Berlin, TIB 4/3-1, Gustav-Meyer-Allee 25, 13355 Berlin, Germany.
Benchtop volatilomics supercharged: How machine learning based design of experiment helps optimizing untargeted GC-IMS gas phase metabolomics
Journal: Talanta, https://doi.org/10.1016/j.talanta.2024.125788, IF: 6,1
Hadi Parastar1,2, Philipp Weller1
1Department of Chemistry, Sharif University of Technology, P.O. Box 11155-9516, Tehran, Iran
2Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163, Mannheim, Germany
Isolation, characterisation and description of the roseoflavin producer Streptomyces berlinensis sp. nov.
Journal: Environmental Microbiology Reports, DOI: 10.1111/1758-2229.13266, IF: 4,06
Jimmy Jonathan Liunardo1, Sebastien Messerli1, Ann-Kathrin Gregotsch1, Sonja Lang1, Kerstin Schlosser1, Christian Rückert-Reed2, 3, Tobias Busche2, Jörn Kalinowski3, Martin Zischka4, Philipp Weller4, Imen Nouioui5, Meina Neumann-Schaal5, Chandra Risdian6, 7, Joachim Wink6, 8, Matthias Mack1
1Institute for Technical Microbiology, Department of Biotechnology, Mannheim University of Applied Sciences, Mannheim, Germany.
2Medical School East Westphalia-Lippe, Bielefeld University, Bielefeld, Germany.
3Technology Platform Genomics, Center for Biotechnology, Bielefeld University, Bielefeld, Germany.
4Institute for Instrumental Analytics and Bioanalytics, Department of Biotechnology, Mannheim University of Applied Sciences, Mannheim, Germany.
5Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
6Department of Microbial Strain Collection, Helmholtz Centre for Infection Research, Braunschweig, Germany.
7Research Center for Applied Microbiology, National Research and Innovation Agency (BRIN), Bandung, Indonesia.
8German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig, Germany.
Investigation of interfacial mass transfer phenomena applying non-invasive Raman imaging and density gradient theory (Kopie 1)
Journal: Chemical Engineering Science, https://doi.org/10.1016/j.ces.2023.119672, IF: 4,9
J. Deuerling1, A. Alsalih1, R. Nagl2, T. Zeiner2, J.-U. Repke3, M. Rädle1
1Center for Mass Spectrometry and Optical Spectroscopy – CeMOS, University of Applied Sciences, Mannheim 68163, Germany
2Process Systems Engineering, Graz University of Technology, Graz 8010, Austria
3Process Dynamics and Operations Group – dbta, Technische Universität Berlin, Berlin 10623, Germany
pyM2aia: Python interface for mass spectrometry imaging with focus on deep learning
Journal: Bioinformatics, https://doi.org/10.1093/bioinformatics/btae133, IF: 6,9
Jonas Cordes1,2, Thomas Enzlein3, Carsten Hopf2,3,4, Ivo Wolf1
1Faculty of Computer Science, Mannheim University of Applied Sciences, Mannheim 68163, Germany
2Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany
3Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, Mannheim, Germany
4Medical Faculty, Heidelberg University, Heidelberg 69120, Germany
Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction
Journal: Journal of Muscle Research and Cell Motility, https://doi.org/10.1007/s10974-024-09665-9, IF: 2,7
Rüdiger Rudolf1, 2 ,3, Isis C. Kettelhut4 and Luiz Carlos C. Navegantes5
1Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Interdisciplinary Center for Neurosciences, Heidelberg University, 69117 Heidelberg, Germany
3Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim Heidelberg University, 69167 Mannheim, Germany
4Department of Biochemistry & Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto-SP, 14049900 Brazil
5Department of Physiology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto-SP, 14049900 Brazil
Automated 2D peak detection in gas chromatography-ion mobility spectrometry through persistent homology
Journal: Analytica Chimica Acta, https://doi.org/10.1016/j.aca.2024.342204, IF: 6,9
Hadi Parastar1,2, Joscha Christmann2, Philipp Weller2
1Department of Chemistry, Sharif University of Technology, P.O. Box 11155-9516, Tehran, Iran
2Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163, Mannheim, Germany
Surgical phase and instrument recognition: how to identify appropriate dataset splits
Journal: Int J CARS, https://doi.org/10.1007/s11548-024-03063-9, IF: 3,0
Georgii Kostiuchik1 ,2, Lalith Sharan3, 4, Benedikt Mayer5, Ivo Wolf6, Bernhard Preim5, Sandy Engelhardt3, 4
1 Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany. georgii.kostiuchik@med.uni-heidelberg.de
2 DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany. georgii.kostiuchik@med.uni-heidelberg.de
3 Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany
4 DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
5 Department of Simulation and Graphics, University of Magdeburg, Magdeburg, Germany
6 Department of Computer Science, Mannheim University of Applied Sciences, Mannheim, Germany
PerSurge (NOA-30) phase II trial of perampanel treatment around surgery in patients with progressive glioblastoma
Journal: BMC Cancer 24, https://doi.org/10.1186/s12885-024-11846-1, IF: 3,8
Sophie Heuer1, 2, Ina Burghaus3, Maria Gose3, Tobias Kessler1, 2, Felix Sahm4, 5, Philipp Vollmuth6, Varun Venkataramani1, 2, 7, Dirk Hoffmann1, 2, Matthias Schlesner8, 9, Miriam Ratliff2, 10, Carsten Hopf11, 12,13, Ulrich Herrlinger14, Franz Ricklefs15, Martin Bendszus6, Sandro M. Krieg16, Antje Wick1, Wolfgang Wick1, 2, Frank Winkler17, 18
1 Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
2 Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
3 Coordination Centre for Clinical Trials (KKS) Heidelberg, 69120, Heidelberg, Germany.
4 Department of Neuropathology, University Hospital Heidelberg, INF 224, 69120, Heidelberg, Germany.
5 CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), Geman Cancer Research Center (DKFZ), Heidelberg, Germany.
6 Department of Neuroradiology, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
7 Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
8 German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
9 Biomedical Informatics, Data Mining and Data Analytics, University of Augsburg, Augsburg, Germany.
10 Neurosurgery Clinic, University Hospital Mannheim, 68167, Mannheim, Germany.
11 Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.
12 Medical Faculty, Heidelberg University, Heidelberg, Germany.
13 Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
14 Division of Clinical Neurooncology, Department of Neurology and Centre of Integrated Oncology, University Hospital Bonn, Bonn, Germany.
15 Department of Neurosurgery, University Hospital Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
16 Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
17 Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany. Frank.Winkler@med.uni-heidelberg.de.
18 Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. Frank.Winkler@med.uni-heidelberg.de.
High-Throughput Miniaturized Synthesis of PROTAC-Like Molecules
Journal: Small, https://doi.org/10.1002/smll.202307215, IF: 13,3
Ye Tian1, Maximilian Seifermann 1, Liana Bauer1, Charlotte Luchena1, Janne J. Wiedmann1, Stefan Schmidt2, Alexander Geisel2, Sergii Afonin3, Julius Höpfner1, Marius Brehm1, Xinyong Liu4, Carsten Hopf2, Anna A. Popova1, Pavel A. Levkin1
1Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
2Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), University of Applied Sciences Mannheim, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
3Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany
4Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Wenhuaxi Road 44, Jinan, 250012 China
Myosin Va: Capturing cAMP for synaptic plasticity
Journal: Frontiers in Physiology, 10.3389/fphys.2023.1342994, IF: 4,0
Rüdiger Rudolf1,2,3
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany
2Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany
3Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany
Investigating the impact of spectral data pre-processing to assess honey botanical origin through Fourier transform infrared spectroscopy (FTIR)
Journal of Food Composition and Analysis, https://doi.org/10.1016/j.jfca.2023.105276
A.S. Tsagkaris 1, K. Bechynska 1, D.D. Ntakoulas 2 4, I.N. Pasias 2, P. Weller 3, C. Proestos 4,
J. Hajslova 1
1Department of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Czech Republic
2General Chemical Lab of Research and Analysis, Lamia, Greece
3Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Germany
4Food Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Greece
Evaluation of IMS drift tube temperature on the peak shape of high boiling fragrance compounds towards allergen detection in complex cosmetic products and essential oils
Journal: Talanta, Volume 257, https://doi.org/10.1016/j.talanta.2023.124397
Charlotte C. Capitain1, Martin Zischka1, Cengiz Sirkeci2, Philipp Weller1
1Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2G.A.S. Gesellschaft für Analytische Sensorsysteme mbH, 44227 Dortmund, Germany
A methodological approach to preprocessing FTIR spectra of adulterated sesame oil
Journal: Food Chemistry, Volume 419. https://doi.org/10.1016/j.foodchem.2023.136055
Rasool Khodabakhshian1, Hajarsadat Seyedalibeyk Lavasani1, Philipp Weller2
1Department of Biosystems Engineering, Ferdowsi University of Mashhad, 9177948978 Mashhad, Iran
2Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
Synthesis of large scale 3D microscopic images of 3D cell cultures for training and benchmarking
Journal: PLOS ONE, https://doi.org/10.1371/journal.pone.0283828
Roman Bruch1, Florian Keller2, Moritz Böhland1, Mario Vitacolonna2, Lukas Klinger1, Rüdiger Rudolf2, Markus Reischl1
1Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
2Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany
PLG-ViT: Vision Transformer with Parallel Local and Global Self-Attention
Journal: Sensors 2023, 23(7), 3447; https://doi.org/10.3390/s23073447
Nikolas Ebert1,2,Didier Stricker2, Oliver Wasenmüller1
1Research and Transfer Center CeMOS, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Department of Computer Science, RPTU Kaiserslautern-Landau, 67663 Kaiserslautern, Germany
Investigating the impact of spectral data pre-processing to assess honey botanical origin through Fourier transform infrared spectroscopy (FTIR)
Journal: Journal of Food Camposition and Analysis, Volume 19. https://doi.org/10.1016/j.jfca.2023.105276
A.S. Tsagkaris1, K. Bechynska1, D.D. Ntakoulas2,4, I.N. Pasias2, P. Weller3, C. Proestos4,
J. Hajslova1
1Department of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6 – Dejvice, Prague, Czech Republic
2General Chemical Lab of Research and Analysis, Lamia, Timfristou 181, Lamia, 35131, Greece
3Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
4Food Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, 15772 Athens, Greece
The Ca2+ channel TRPV4 is dispensable for Ca2+ influx and cell volume regulation during hypotonic stress response in human keratinocyte cell lines
Journal: Cell Calcium 2023 May;111:102715., doi: 10.1016/j.ceca.2023.102715
Dirk Ritzmann1, Magdalena Jahn1,2, Susanne Heck1, Cristina Jung3, Tiziana Cesetti4,5,
Nathalie Couturier4,5, Rüdiger Rudolf4,5, Naemi Reuscher2, Claudia Buerger2, Oliver Rauh3,
Torsten Fauth1
1BRAIN Biotech AG, Zwingenberg, Germany
2Department of Dermatology, Venerology and Allergology, University Hospital Frankfurt, Frankfurt am Main, Germany
3Membrane Biophysics, Department of Biology, TU Darmstadt, Darmstadt, Germany
4Institute of Molecular and Cell Biology, Hochschule Mannheim, Mannheim, Germany
5Center for Mass Spectrometry and Optical Spectroscopy, Hochschule Mannheim, Mannheim, Germany
UV/VIS-Spectroscopic Inline Measurement for the Detection of Fouling Processes during the Polymerization of N-Vinylpyrrolidone
Journal: Reactions 2023, 4(1), 176-188; https://doi.org/10.3390/reactions4010011
Erik Spoor1, Stefan Welzel 2, Ulrich Nieken2, Matthias Rädle1
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), University of Applied Science Mannheim, 68163 Mannheim, Germany
2Institute of Chemical Process Engineering (ICVT), University of Stuttgart, 70199 Stuttgart, Germany
A Caged In-Source Laser-Cleavable MALDI Matrix with High Vacuum Stability for Extended MALDI-MS Imaging
Journal: Angewandte Chemie, https://doi.org/10.1002/anie.202217047
Q. Zhou1, A. Fülöp1, C. Hopf1,4,5, S. Rizzo2, M. Rittner2, H.Gillandt2, J. Oetjen3
1Centerfor Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Str.10, 68163 Mannheim
2Sirius Fine Chemicals SiChem GmbH, Fahrenheitstr.1, 28359 Bremen
3Bruker Daltonics GmbH & Co. KG, Fahrenheitstr. 4, 28359 Bremen
4Medical Faculty, Heidelberg University, Im Neuenheimer Feld 672, 69120 Heidelberg
5Mannheim Centerfor Translational, Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Straße13–17,68167 Mannheim
Multivariate curve resolution for kinetic modeling and scale-up prediction
Journal: Journal of Flow Chemistry (2023), https://doi.org/10.1007/s41981-022-00252-y
Lisa Schulz1, Norbert Kockmann1, Lisa Schulz2, Thorsten Röder2, Philipp Stähle3, Sven Reining3, Mathias Sawall4
1Laboratory of Equipment Design, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227, Dortmund, Germany
2Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, 68163, Mannheim, Germany
3BASF SE, 67056, Ludwigshafen am Rhein, Germany
4Institute of Mathematics, University of Rostock, 18057, Rostock, Germany
Two peak elution behavior of a monoclonal antibody in cation exchange chromatography as a screening tool for excipients
Journal: Journal of Chromatography B(2023).Vol. 1214, 123563. doi:10.1016/j.jchromb.2022.123563
Carolin Stange1, Supriyadi Hafiz 2, Nelli Erwin 2, Mathias Hafner 3, Christian Frech 4
1Institute for Biochemistry, University of Applied Sciences Mannheim, 68163 Mannheim, Germany
2Merck KGaA, 64293 Darmstadt, Germany
3Institute of Molecular Biology and Cell Culture Technology, University of Applied Sciences Mannheim, 68163 Mannheim, Germany
Establishing Reliable Research Data Management by Integrating Measurement Devices Utilizing Intelligent Digital Twins
Journal: Sensors 2023, 23 (1), 468; https://doi.org/10.3390/s23010468
Joel Lehmann, Stefan Schorz, Alessa Rache, Tim Häusermann, Matthias Rädle, Julian Reichwald
Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
Development and In Vitro Differentiation of Schwann Cells
Journal: Cells 2022 (11,23), https://doi.org/10.3390/cells11233753
Sarah Janice Hörner1,2,3, Nathalie Couturier1,2,3, Daniele Caroline Gueiber1,2,3,4, Mathias Hafner1,5, Rüdiger Rudolf1,2,3,5
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Interdisciplinary Center for Neurosciences, Heidelberg University, 69120 Heidelberg, Germany
3Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
4Department of Electronics Engineering, Federal University of Technology Paraná, Ponta Grossa 84017-220, Brazil
5Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, 69117 Heidelberg, Germany
Deep-learning assisted data augmentation of spectral data for the authentication and quality analysis of food products
Journal: Lebensmittelchemie 76(S2):S2-181-S2-181, doi:10.1002/lemi.202259137
Sascha Rohn, Philipp Weller, Leslie Simon
Hochschule Mannheim, Paul-Wittsack-Straße 10, 68163 Mannheim
Influence of Refractive Index Differences on the Signal Strength for Raman-Spectroscopic Measurements of Double Emulsion Droplets
Journal: Applied Sciences, https://doi.org/10.3390/app12189056
Thomas Hufnagel1, Matthias Rädle1, Heike P. Karbstein2
1CeMOS—Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Science, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
2Institute of Process Engineering in Life Science, Chair I: Food Process Engineering, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany
Prediction of Fluorescent Ki67 Staining in 3D Tumor Spheroids
Journal: Current Directions in Biomedical Engineering, Band 8 Heft 2, https://doi.org/10.1515/cdbme-2022-1078
Roman Bruch1, Mario Vitacolonna2, Rüdiger Rudolf2, Markus Reischl3
1Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
2Center for Mass Spectrometry and Optical Spectroscopy (CeMOS) and Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany
3Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
Multivariate data analysis of low and high field NMR data of brewed coffee from fermented coffee beans
Journal: Lebensmittelchemie, Volume76, IssueS: https://doi.org/10.1002/lemi.202259089
Catherine Kiefer1, Sascha Rohn2, Philipp Weller1
1HochschuleMannheim, Institut für Instrumentelle Analytik/Competency Center for Chemometrics CHARISMA, Mannheim, Germany
2TU Berlin, Institut für Lebensmittelchemie, Berlin, Germany
VOC-basiertes Profiling von Zitrusprodukten mittels GC-MS-IMS & maschinellem Lernen
Journal: Lebensmittelchemie 76(S2):S2-183-S2-184, doi:10.1002/lemi.202259139
L. Bodenbender2, P. Weller1, S. Rohn1
1HochschuleMannheim, Institut für Instrumentelle Analytik/Competency Center for Chemometrics CHARISMA, Mannheim, Germany
2TU Berlin, Institut für Lebensmittelchemie, Berlin, Germany
gc-ims-tools - A new Python package for chemometric analysis of GC-IMS data
Journal: Food Chemistry, Volume 394, https://doi.org/10.1016/j.foodchem.2022.133476
JoschaChristmann1,2 ,SaschaRohn2,3, PhilippWeller1
1Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Paul–Wittsack-Straße 10, 68163 Mannheim, Germany
2Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany
3Department of Food Chemistry and Analysis, Institute of Food, Technology and Food Chemistry, Technische Universität Berlin, TIB 4/3-1, Gustav-Meyer-Allee 25, 13355 Berlin, Germany
Continuous diameter increase reactor – a reactor concept for maximizing productivity by a controlled diameter extension
Journal: Journal of Flow Chemistry (2022), https://doi.org/10.1007/s41981-022-00224-2
Marcus Hafner1, Fabian Wolff1, Thorsten Röder1
1Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163, Mannheim, Germany
Marker-Free, Molecule Sensitive Mapping of Disturbed Falling Fluid Films Using Raman Imaging
Journal: Sensors 2022, 22(11), https://doi.org/10.3390/s22114086
Marcel Nachtmann1, Sebastian Sold1, Felix Wühler1, Stephan Scholl2, Matthias Rädle1
1Center for Mass Spectrometery and Optical Spectroscopy, Hochschule Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Institute for Chemical and Thermal Process Engineering, Technische Universität Braunschweig, 38106 Braunschweig, Germany
Traditional Grain-Based vs. Commercial Milk Kefirs, How Different Are They?
Journal: Applied Science, https://doi.org/10.3390/app12083838
Fatemeh Nejati1, Charlotte C. Capitain2, Jannike Lea Krause3, Gi-Ung Kang3, René Riedel3, Hyun-Dong Chang3,4, Jens Kurreck5, Stefan Junne1, Philipp Weller2, Peter Neubauer1
1Bioprocess Engineering, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany
2Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
3German Rheumatism Research Center Berlin, A Leibniz Institute—DRFZ, Schwiete Laboratory for Microbiota and Inflammation, 10117 Berlin, Germany
4Chair of Cytometry, Institute of Biotechnology, Technische Universität Berlin, 10623 Berlin, Germany
5Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany
Pesticide handling and waste management: a case study on DDT and HCHs from the Southern Caucasus
Journal: SN Applied Sciences, https://doi.org/10.1007/s42452-022-04999-w
Daniela Lud1, Annika Schwemm2, Besik Kalandadze3, Elbay Babaev4, Marcel Pierre Simon2, Philipp Weller5, Rolf-Alexander Düring2
1Faculty of Communication and Environment, Rhein-Waal University of Applied Sciences, Hochschule Rhein-Waal, Kamp-Lintfort, Germany
2Institute of Soil Science and Soil Conservation, Justus Liebig Universitat Giessen, Giessen, Germany
3Department of Soil Geography, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia
4Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences, Baku, Azerbaijan
5Institute of Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, Hochschule Mannheim, Mannheim, Germany
Volatilomics-Based Microbiome Evaluation of Fermented Dairy by Prototypic Headspace-Gas Chromatography–High-Temperature Ion Mobility Spectrometry (HS-GC-HTIMS) and Non-Negative Matrix Factorization (NNMF)
Journal: Metabolites, https://doi.org/10.3390/metabo12040299
Charlotte C. Capitain1, Fatemeh Nejati2, Martin Zischka1, Markus Berzak1, Stefan Junne2, Peter Neubauer2, Philipp Weller1
1Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Bioprocess Engineering, Institute of Biotechnology, Technische Universität Berlin, Ackerstrasse 76 ACK 24, 13355 Berlin, Germany
3D Melanoma Cocultures as Improved Models for Nanoparticle-Mediated Delivery of RNA to Tumors
Journal: 10.3390/cells11061026
Maximilian E. A. Schäfer1, Florian Keller1, Jens Schumacher2, Heinrich Haas2, Fulvia Vascotto3, Ugur Sahin2, Mathias Hafner1,4and Rüdiger Rudolf1,4,5
1Institute of Molecular and Cell Biology, Hochschule Mannheim, 68163 Mannheim, Germany
2Biopharmaceutical New Technology (BioNTech) SE, 55131 Mainz, Germany
3Translational Oncology (TRON), University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
4Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Hochschule Mannheim, 68163 Mannheim, Germany
LPS‑induced lipid alterations in microglia revealed by MALDI mass spectrometry‑based cell fingerprinting in neuroinflammation studies
Journal: Nature Research (2022)
Martina Blank1,2*, Thomas Enzlein1, Carsten Hopf1,3
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul‑Wittsack Str. 10, 68163 Mannheim, Germany.
2Structural Molecular Biology Laboratory (LABIME), Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, SC 88040‑900, Brazil.
3Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany.
Label-free cell assays to determine compound uptake or drug action using MALDI-TOF mass spectrometry
Journal: Nature Protocols (2021)
Melissa Unger1, Martina Blank1, Thomas Enzlein1, Carsten Hopf1
1Faculty of Computer Science, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma
Journal: Theranostics, doi:10.7150/thno.60679
Verena Panitz1,2*, Saša Končarević3*, Ahmed Sadik1,4*, Dennis Friedel1,4, Tobias Bausbacher5, Saskia Trump6, Vadim Farztdinov3#, Sandra Schulz5, Philipp Sievers7,8, Stefan Schmidt5, Ina Jürgenson1,2, Stephan Jung3, Karsten Kuhn3, Irada Pflüger9, Suraj Sharma10, Antje Wick2, Pauline Pfänder1,4, Stefan Selzer3, Philipp Vollmuth9, Felix Sahm7,8, Andreas von Deimling7,8, Ines Heiland10, Carsten Hopf5, Peter Schulz-Knappe3§, Ian Pike11, Michael Platten12,13, Wolfgang Wick2,14, Christiane A. Opitz1,2
1. DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
2. Department of Neurology and National Center for Tumor Diseases, Heidelberg University Hospital, 69120 Heidelberg, Germany.
3. Proteome Sciences R&D GmbH & Co. KG, Altenhöferallee 3, 60438 Frankfurt/Main, Germany.
4. Faculty of Bioscience, Heidelberg University, 69120 Heidelberg, Germany.
5. Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
6. Molecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.
7. Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
8. Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
9. Department of Neuroradiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
10. Department of Arctic and Marine Biology, UiT, The Arctic University of Norway, 9037 Tromsø, Norway.
11. Proteome Sciences plc, 5 Dashwood Lang Road, Bourne Business Park, Addlestone, Surrey KT15 2HJ, United Kingdom.
12. Department of Neurology, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
13. DKTK Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
14. Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
*These authors contributed equally to this work.
#Current address: Core Facility - High-Throughput Mass Spectrometry, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), 10117 Berlin, Germany.
§Current address: Mittelorbroich 125, 47839 Krefeld, Germany.
M2aia-Interactive, fast, and memory-efficient analysis of 2D and 3D multi-modal mass spectrometry imaging data
Journal: Gigascience, 10.1093/gigascience/giab049
J. Cordes1,2, T. Enzlein3, Ch. Marsching3, M. Hinze1, S. Engelhardt4, C. Hopf3, I. Wolf1
1Faculty of Computer Science, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.
2Medical Faculty Mannheim, University Heidelberg, Theodor Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
3Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.
4Working Group "Artificial Intelligence in Cardiovascular Medicine" (AICM), University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
MIR spectroscopy versus MALDI-ToF-MS for authenticity control of honeys from different botanical origins based on soft independent modelling by class analogy (SIMCA) – A clash of techniques?
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, https://doi.org/10.1016/j.saa.2021.120225
R. Brendel1,2,4 , S. Schwolow1, N. Gerhardt1,5, J. Schwab4, P. Rau4, M. Oest2, S. Rohn2,3, P. Weller1
1Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
2Institute of Food Chemistry, Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany
3Department of Food Chemistry and Analysis, Institute of Food Technology and Food Chemistry, Technische Universität Berlin, TIB 4/3-1, Gustav-Meyer-Allee 25, 13355 Berlin, Germany
4Micro-Biolytics GmbH, Schelztorstraße 54, 73728 Esslingen am Neckar, Germany
5Bavarian Health and Food Safety Authority (LGL), Veterinärstr. 2, 85764 Oberschleißheim, Germany
**Editor’s Pick 2021** - A Novel Optical Tissue Clearing Protocol for Mouse Skeletal Muscle to Visualize Endplates in Their Tissue Context
Journal: Frontiers in Cellular Neuroscience, doi.org/10.3389/fncel.2019.00049
M. P. I. Williams1,*, M. Rigon1,*, T. Straka1,2,*, S. J. Hörner1,2,*, M. Thiel3, N. Gretz4,5, M. Hafner1,5, M. Reischl6, R. Rudolf1,2,5,7
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany
2Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany
3Department of Anesthesiology and Surgical Intensive Care Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
4Medical Faculty Mannheim, Medical Research Center, Heidelberg University, Mannheim, Germany
5Medical Faculty Mannheim, Institute of Medical Technology, Mannheim University of Applied Sciences, Mannheim, Germany
6Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
7Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
**Editor’s Pick 2021**
Die Veröffentlichung wurde vom Frontiers Editorial Office als Cellular Neuropathology Editor’s Pick 2021ausgewählt. Damit zeichnet die Redaktion “Artikel mit hervorragender wissenschaftlicher Qualität aus, die repräsentativ für die Arbeit in einem bestimmten Bereich sind".
Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation
Journal: Frontiers in Human Neuroscience, doi: 10.3389/fnhum.2021.667709
E. von Molitor1, K. Riedel2, M. Krohn2, M. Hafner1, R. Rudolf1,3, T. Cesetti1
1Institute of Molecular and Cell Biology, Hochschule Mannheim, Mannheim, Germany.
2BRAIN AG, Zwingenberg, Germany.
3Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany.
Simultaneous self-optimisation of yield and purity through successive combination of inline FT-IR spectroscopy and online mass spectrometry in flow reactions
Journal: Journal of Flow Chemistry, doi.org/10.1007/s41981-021-00140-x
V. Fath1, P. Lau2, Ch. Greve2, P. Weller3, N. Kockmann4, T. Röder1
1Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163, Mannheim, Germany
2Merck KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany
3Institute of Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163, Mannheim, Germany
3Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 68, 44227, Dortmund, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Extracellular Matrix Components Regulate Bone Sialoprotein Expression in MDA-MB-231 Breast Cancer Cells
Journal: Cells, https://doi.org/10.3390/cells10061304
F. Keller1,2,*, R. Bruch1,*, F. Clauder3, M. Hafner1,2, R. Rudolf1,2
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, 68167 Mannheim, Germany
3Immundiagnostik AG, 64625 Bensheim, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Oscillating droplet reactor – towards kinetic investigations in heterogeneous catalysis on a droplet scale
Journal: Reaction Chemestry & Engineering, doi: doi.org/10.1039/D0RE00466A
T. Klement1,*, Sch. Hanf2, F. Wolff1, N. Kockmann3, St. Schunk2, T. Röder1
1Mannheim University of Applied Sciences, Institute of Chemical, Process Engineering, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
2hte GmbH, Kurpfalzring 104, 69123 Heidelberg, Germany
3Technische Universität Dortmund, Fakultät für Bio- und Chemieingenieurwesen, Apparatedesign, Emil-Figge-Straße 68, 44227 Dortmund, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Nitrogen monoxide as dopant for enhanced selectivity of isomeric monoterpenes in drift tube ion mobility spectrometry with 3 H ionization
Journal: Analytical and Bioanalytical Chemistry, doi: 10.1007/s00216-021-03306-7
R. Brendel1,*, S. Rohn2, P. Weller1
1Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, Paul-Wittsack-Strasse 10, 68163, Mannheim, Germany
2Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146, Hamburg, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Preparation, Drug Treatment, and Immunohistological Analysis of Tri-Culture Spheroid 3D Melanoma-Like Model
Journal: Meladoma, doi.org/10.1007/978-1-0716-1205-7_13
M. Schäfer1,*, J. Klicks1,*, M. Hafner1, R. Rudolf1
1Institute of Molecular and Cell BiologyHochschule Mannheim, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor
Journal: Frontiers in Physiology, doi.org/10.3389/fphys.2021.626707
T. Straka1,2,3,*, Ch. Schröder4, A. Roos5,6, L. Kollipara4, A. Sickmann4,7,8, M. P. I. Williams1, M. Hafner1, M. M. Khan1,2,3*, R. Rudolf1,2,3*
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany
2Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany
3Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany
4Leibniz-Institut für Analytische Wissenschaften—ISAS—e.V., Dortmund, Germany
5Department of Neuropediatrics, University Hospital Essen, Essen, Germany
6Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
7Department of Chemistry, College of Physical Sciences, University of Aberdeen, Aberdeen, United Kingdom
8Medizinische Fakultät, Medizinische Proteom-Center (MPC), Ruhr-Universität Bochum, Bochum, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Kinetic Measurement of Acrylic Acid Polymerization at High Concentrations under Nearly Isothermal Conditions in a Pendula Slug Flow Reactor
Journal: Industrial & Engineering Chemistry Research, doi: 10.1021/acs.iecr.0c04732
T. Klement1, N. Kockmann2, Ch. Schwede3, T. Röder1
1Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Mannheim
2Faculty of Biochemical and Chemical Engineering, Laboratory of Equipment Design, TU Dortmund University, Dortmund
3BASF SE, RCP/ME-B01, Ludwigshafen am Rhein
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Fast Nanoliter-Scale Cell Assays Using Droplet Microarray–Mass Spectrometry Imaging
Journal: Advanced Biology, doi.org/10.1002/adbi.202000279
C. Ramallo Guevara1, D. Paulssen2, A. Popova2, C. Hopf1, P. Levkin2
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences Paul-Wittsack Str. 10, 68163 Mannheim, Germany
2Karlsruhe Institute of Technology (KIT) Institute of Biological and Chemical Systems – Functional Molecular, Systems (IBCS-FMS) Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
Volatilomic Profiling of Citrus Juices by Dual-Detection HS-GC-MS-IMS and Machine Learning—An Alternative Authentication Approach
Journal: Journal of Agricultural and Food Chemistry, doi.org/10.1021/acs.jafc.0c07447
R. Brendel1,*, S. Schwolow2, S. Rohn2, P. Weller1
1Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
2Institute of Food Chemistry, Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Year 2020
Evaluation of semi-supervised learning using sparse labeling to segment cell nuclei
Journal: Current Directions in Biomedical Engineering, doi.org/10.1515/cdbme-2020-3103
R. Bruch1, R. Rudolf1, R. Mikut2, M. Reischl2
1Institute of Molecularand Cell Biology, Faculty of Biotechnology, Mannheim University ofApplied Sciences, Mannheim, Germany
2Institute for Automation and AppliedInformatics, Karlsruhe Institute of Technology, Karlsruhe, Germany
Recent developments of novel matrices and on-tissue chemical derivatization reagents for MALDI-MSI
Journal: Analytical and Bioanalytical Chemistry, doi: 10.1007/s00216-020-03023-7
Q. Zho1, A. Fülöp1, C. Hopf1
1Zentrum für Massenspektrometrie und optische Spektroskopie (CeMOS), Fachhochschule Mannheim, Paul-Wittsack-Str. 10, 68163, Mannheim, Deutschland
Comparision of PLSR, MCR-ALS and Kernel-PLSR for the quantification of allergenic fragrance compounds in complex cosmetic products based on nonlinear 2D GC-IMS data
Journal: Chemometrics and Intelligent Laboratory Systems, doi: 10.1016 / j.chemolab.2020.104128
R. Brendel1,*, S. Schwolow1, S. Rohn2, P. Weller1
1Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163, Mannheim, Germany
2Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, 20146, Hamburg, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images
Journal: Analytical Chemistry 2020, doi: 10.1021 / acs.analchem.0c02585
T. Enzlein1,*, J. Cordes1,*, B. Munteanu1, W. Michno2, L. Serneels3, B. De Strooper3, J. Hanrieder4, I. Wolf5, L. Chávez-Gutiérrez3, C. Hopf1
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany
2Klinik für Psychiatrie und Neurochemie, Sahlgrenska-Akademie an der Universität Göteborg, Mölndal-Krankenhaus, Haus V3, Mölndal 43180, Schweden
3KU Leuven-VIB-Zentrum für Hirn- und Krankheitsforschung, VIB, Leuven 3000, Belgien ; Klinik für Neurowissenschaften, Leuven Institut für Neurowissenschaften und Krankheiten, KU Leuven, Leuven 3000, Belgien ; UK Dementia Research Institute an der UCL, University College London, London WC1E 6BT UK
4Klinik für Psychiatrie und Neurochemie, Sahlgrenska-Akademie der Universität Göteborg, Krankenhaus Mölndal, Haus V3, Mölndal 43180, Schweden ; Abteilung für neurodegenerative Erkrankungen, University College London Queen Square Institut für Neurologie, Queen Square, London WC1N 3BG, Vereinigtes Königreich
5Fakultät für Informatik, Fachhochschule Mannheim, Paul-Wittsack-Straße 10, Mannheim 68163
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Spatially resolved mass spectrometry analysis of amyloid plaque-associated lipids
Journal: Journal of Neurochemistry, doi: 10.1111 / jnc.15216
M. Blank2, C. Hopf1
1Zentrum für Massenspektrometrie und optische Spektroskopie (CeMOS), Fachhochschule Mannheim, Paul-Wittsack-Str. 10, 68163, Mannheim, Deutschland.
2Center for Struktural Molecular (CEBIME/PROPESQ), Federal University of Santa Catarina, Florianopolis, Brazil.
An alternative pathway for sweet sensation: possible mechanisms and physiological relevance
Journal: European Journal of Physiology, doi:10.1007/s00424-020-02467-1
E. von Molitor1,*, K. Riedel2, M. Krohn2, R. Rudolf1,3, M. Hafner1, T. Cesetti1
1Institut für Molekular- und Zellbiologie, Hochschule Mannheim, 68163, Mannheim
2BRAIN AG, 64673, Zwingenberg, Deutschland
3Interdisziplinäres Zentrum für Neurowissenschaften, Universität Heidelberg, 69120, Heidelberg
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Feasibility Study for a Chemical Process Particle Size Characterization System for Explosive Environments Using Low Laser Power
Journal: Micromachines, doi:10.3390/mi11100911
J. Ross-Jones1,2, T. Teumer1,2, S. Wunsch1, L. Petri1, H. Nirschl2, M.J. Krause2, F.-J. Methner3, M. Rädle1
1Zentrum für Massenspektrometrie und optische Spektroskopie, Fachhochschule Mannheim, Paul-Wittsack-Straße 10, 68163 Mannheim.
2Forschungsgruppe Gitter Boltzmann, Institut für Maschinenbau, Verfahrenstechnik und Mechanik, Karlsruher Institut für Technologie, Straße am Forum 8, 76131 Karlsruhe.
3Lehrstuhl für Brauwissenschaft, Institut für Lebensmitteltechnologie und Lebensmittelchemie, Technische Universität Berlin, Seestraße 13, 13353 Berlin.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Self-optimization of organic syntheses in an automated-flow microreactor system using Simplex and DoE
Journal: Chemie Ingenieur Technik, doi: 10.1002/cite.202055124
V. Fath1,*, P. Lau2, C. Greve2, N. Kockmann3
1Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
2Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt/Germany
3Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Kinetic measurements of acrylic acid polymerization in a pendular slug reactor
Journal: Chemie Ingenieur Technik, doi: 10.1002 / cite.202055217
T. Klement1,*, T. Röder1, N. Kockmann2
1Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
2Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
A Scaffold-Free 3-D Co-Culture Mimics the Major Features of the Reverse Warburg Effect In Vitro
Journal: Cells, doi: 0.3390/cells9081900
F. Keller1,2,*, R. Bruch, R. Schneider3, J. Meier-Hubberten3, M. Hafner1,2, R. Rudolf1,2
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Institute of Medical Technology, Medical Faculty Mannheim of Heidelberg University and Mannheim University of Applied Sciences, 68167 Mannheim, Germany
3TIP Oncology, Merck Healthcare KGaA, 64289 Darmstadt, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Gas-phase volatilomic approaches for quality control of brewing hops based on simultaneous GC-MS-IMS and machine learning
Journal: Analytical and Bioanalytical Chemistry, doi: 10.1007 / s00216-020-02842-y
R. Brendel1,*, S. Schwolow1, S. Rohn2, P. Weller1
1Paul-Wittsack-Straße 10, 68163, Mannheim
2Institut für Lebensmittelchemie, Hamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146, Hamburg
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs.
Journal: Analytical Chemistry, https://doi.org/10.1021/acs.analchem.0c02186
M. S. Unger1,2,3,*, L. Schumacher1, T. Enzlein1, D. Weigt1, M.J. Zamek-Gliszczynski4, M. Schwab5,6,7, A.T. Nies5,6, G. Drewes3, S. Schulz1, F.B.M. Reinhard3, C. Hopf1,2,*
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany
2Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
3Cellzome – a GlaxoSmithKline company, Meyerhofstr. 1, 69177 Heidelberg, Germany
4Drug Metabolismand Pharmacokinetics, GlaxoSmithKline, 1250 S Collegeville Rd, Collefeville, Pennsylvania 19426, United States
5Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany
6iFit Cluster of Excellence (EXC2180) “Image Guided and Functionally Instructed Tumor Therapies”, University of Tübingen, Tübingen, Germany
7Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tübingen, Geschwister Scholl Platz, 72074 Tübingen, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Recent Advances in Experimental Techniques for Flow and Mass Transfer Analyses in Thermal Separation Systems
Journal: Chemie Ingenieur Technik, doi: https://doi.org/10.1002/cite.202000076
U. Hampel1,2, M. Schubert1, A. Döß1, J. Sohr, V. Vishwakarma1, J.-U. Repke3, S.J. Gerke3, H. Leuner3, M. Rädle4, V. Kapoustina4, L. Schmitt4, M. Grünewald5, J.H. Brinkmann5, D. Plate5, E.Y. Kenig6, N. Lutters6, L. Bolenz6, F. Buckmann, D. Toye7, W. Arlt8, T. Linder8, R. Hoffmann9, H. Klein10, S. Rehfeldt10, T. Winkler10, H.-J. Bart11, D. Wirz11, J. Schulz11, S. Scholl12, W. Augustin12, K. Jasch12, F. Schlüter12, N. Schwerdtfeger12, S. Jahnke12, A. Jupke13, C. Kabatnik13, A.S. Braeuer14, M. D‘Auria14, T. Runowski15, M.F. Casal15, K. Becker15, A.-L. David15, A. Górak16, M. Skiborowski16, K. Groß16, H. Qammar16
1Helmholtz-Zentrum Dresden-Rossendorf, Institut für Fluiddynamik, Bautzner Landstraße 400, 01328 Dresden, Germany.
2Technische Universität Dresden, Institut für Energietechnik, 01062 Dresden, Germany.
3Technische Universität Berlin, Institut für Prozess- und Verfahrenstechnik, Straße des 17. Juni 135, 10623 Berlin, Germany.
4Hochschule Mannheim, Center for Mass Spectrometry and Optical Spectroscopy, John-Deere-Straße 81A, 68163 Mannheim, Germany.
5Ruhr-Universita¨t Bochum, Lehrstuhl für Fluidverfahrenstechnik, Universitätsstraße 150, 44801 Bochum, Germany.
6Universität Paderborn, Fakultat für Maschinenbau, Lehrstuhl für Fluidverfahrenstechnik, Pohlweg 55, 33098 Paderborn, Germany.
7Universite de Liege, Department of Chemical Engineering, Alle edu six Aout, 17B, 4000 Liege 1, Belgium.
8Friedrich-Alexander-Universität Erlangen-Nurnberg, Institute of Separation Science and Technology, Egerlandstraße 3, 91058 Erlangen, Germany.
9Linde Aktiengesellschaft, Engineering Division, Dr.-Carl-von-Linde-Straße 6–14, 82049 Pullach bei München, Germany.
10Technical University of Munich, Department of Mechanical Engineering, Institute of Plant and Process Technology, Boltzmannstraße 15, 85748 Garching, Germany.
11Technische Universität Kaiserslautern, Lehrstuhl für Thermische Verfahrenstechnik, PF 3049, 67653 Kaiserslautern, Germany.
12Technische Universität Braunschweig, Institute for Chemical and Thermal Process Engineering, Langer Kamp 7, 38106 Braunschweig, Germany.
13RWTH Aachen University, Aachener Verfahrenstechnik, Fluidverfahrenstechnik, Forckenbeckstraße 51, 52074 Aachen, Germany.
14Technische Universita¨t Bergakademie Freiberg (TUBAF), Institute of Thermal-, Environmental and Resources’ Process Engineering (ITUN), Leipziger Straße 28, 09599 Freiberg, Germany.
15Bayer AG, Engineering & Technology, Thermal Separation Technologies, 51368 Leverkusen, Germany.
16TU Dortmund University, Department of Biochemical and Chemical Engineering, Laboratory of Fluid Separations, Emil-Figge-Straße 70, 44227 Dortmund, Germany.
Fast Quantification Without Conventional Chromatography, the Growing Power of Mass Spectrometry
Journal: Analytical Chemistry, doi: 10.1021/acs.analchem.0c00877
G. Gachumi1, R.W. Purves1,2, C. Hopf3, A. El-Aneed1
1College of Pharmacy and Nutrition, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada, S7N 5E5.
2Centre for Veterinary Drug Residues, Canadian Food Inspection Agency, 116 Veterinary Rd, Saskatoon, SK, Canada, S7N 2R3.
3Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack-Strasse 10, 68163 Mannheim, Germany.
Lab‐scale microreactor plant for the study of methylations with liquid chloromethane
Journal: Chemical Engineering Technology, doi.org/10.1002/ceat.202000011
M. Sc. C.V. Benzin1,2,*,Prof. Dr.-Ing. N. Kockmann1, Prof. Dr. T. Röder2
1TU Dortmund University, Laboratory of Equipment Design, Emil-Figge-Straße 68, 44227 Dortmund, Germany
2Hochschule Mannheim University of Applied Sciences, Institute of Chemical Process Engineering, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Self-optimising processes and real-timeoptimisation of organic syntheses in a microreactor system using Nelder–Mead and design of experiments
Journal: Reaction Chemistry & Engineering, doi: 10.1039/d0re00081g
V. Fath3,*, N. Kockmann1, J. Otto2, T. Röder3
1Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund, Germany
2Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
3Hochschule Mannheim University of Applied Sciences, Institute of Chemical Process Engineering, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Efficient Kinetic Data Acquisition and Model Prediction: Continuous Flow Microreactors, Inline FT-IR Spectroscopy, and Self-modeling Curve Resolution
Journal: Organic Process Research & Development, doi.org/10.1021/acs.oprd.0c00037
V. Fath1,2, *, P. Lau3, Chr. Greve3, N. Kockmann1, T. Röder2
1Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund/Germany
2Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
3Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt/Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
New Derivatization Reagent for Detection of free Thiol-groups in Metabolites and Proteins in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
Journal: Analytical Chemistry, doi.org/10.1021/acs.analchem.9b05630
A. Fülöp1, T. Bausbacher1, St. Rizzo2, Q. Zhou1, H. Gillandt2, C. Hopf1, M. Rittner2
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Sirius Fine Chemicals SiChem GmbH, 28359 Bremen, Germany
Molecule Sensitive Optical Imaging and Monitoring Techniques-A Review of Applications in Micro-Process Engineering.
Journal: Chemie Ingenieur Technik, doi:10.1002/cite.202000076
M. Nachtmann1, J. Deuerling1,*, M. Rädle1
1Forschungszentrum CeMOS, Fachhochschule Mannheim, Paul-Wittsack-Str. 10, 68163 Mannheim, Deutschland
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Sensing Senses: Optical Biosensors to Study Gustation
Journal: Sensors (Basel), doi: https://doi.org/10.3390/s20071811
E. von Molitor1,*, K. Riedel2, M. Hafner1, R.Rudolf1,3, T. Cesetti1
1Institut für Molekular- und Zellbiologie, Hochschule Mannheim, 68163 Mannheim
2BRAIN AG, 64673 Zwingenberg
3Interdisziplinäres Zentrum für Neurowissenschaften, Universität Heidelberg, 69120 Heidelberg
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Routine Optical Clearing of 3D-Cell Cultures: Simplicity Forward
Journal: Frontiers in Molecular Biosiences, doi.org/10.3389/fmolb.2020.00020
E. Nürnberg1,2,*, M. Vitacolonna1, J. Klicks1,*, E. von Molitor1,*, T. Cesetti1, F. Keller1,*, R. Bruch1,*, T. Ertongur-Fauth3, K. Riedel3, P. Scholz3, T. Lau2, R. Schneider4, J. Meier4, M. Hafner1, R. Rudolf1
1Institut für Molekular- und Zellbiologie, Fakultät für Biotechnologie, Fachhochschule Mannheim, Mannheim
2Zentralinstitut für Seelische Gesundheit, Abteilung für translationale Hirnforschung, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim
3BRAIN AG, Zwingenberg
4TIPP Onkologie, Merck Healthcare KGaA, Darmstadt
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
A paper-based colorimetric sensor array for discrimination of monofloral European honeys based on gold nanoparticles and chemometrics data analysis
Journal: Molecular and Biomolecular Spectroscopy, https://doi.org/10.1016/j.saa.2020.119076
M. Chaharlangi1, J. Tashkhourian1, M. mahdi Bordbar1, R. Brendel2,*, P. Weller2, B. Hemmateenejad1,3
1Abteilung für Chemie, Universität Shiraz, Shiraz 71454, Iran
2Institut für Instrumentelle Analytik und Bioanalytik, Fachhochschule Mannheim, 68163 Mannheim
3Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Analysis of Calcium Signaling in Live Human Tongue Cell 3D-Cultures upon Tastant Perfusion
Journal: Cell Calcium, doi.org/10.1016/j.ceca.2020.102164
E. von Molitor 1,*, E. Nürnberg 1,*, T. Ertongur-Fauth 2, P. Scholz 2, K. Riedel 2, M. Hafner 1, R. Rudolf 1,3, T. Cesetti 1
1Institute of Molecular and Cell Biology, Hochschule Mannheim, 68163 Mannheim, Germany
2 BRAIN AG, 64673 Zwingenberg, Germany
3Interdisciplinary Center for Neurosciences, Heidelberg University, 69120 Heidelberg, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Year 2019
Towards optimized breast cancer 3D spheroid mono- and co-culture models for pharmacological research and screening
Journal of Cellular Biotechnolog, doi: 10.3233/JCB-199001
F. Keller1,*, R. Rudolf1,2, M. Hafner1,2
1Institute of Molecular and Cellular Biology, Mannheim University of Applied Sciences, Mannheim, Germany.
2Institute of Medical Technology of Heidelberg University and Mannheim University of Applied Sciences, Mannheim, Germany.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany.
Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space
Journal: Molecular Pharmaceutics, doi.org/10.1021/acs.molpharmaceut.9b00897
M.S. Unger1,*, Matthias Schwab1,4,5, M.J. Zamek-Gliszczynski1, G. Drewes2, F.B.M. Reinhard2, C. Hopf3, J. Mudunuru3,4, A.T. Nies4
1Drug Metabolism and Disposition, GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States.
2Cellzome, a GlaxoSmithKline Company, 69117 Heidelberg, Germany.
3Center for Mass Spectrometry and Optical Spectroscopy (CeMOS) and Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
4Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
5Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tübingen, 72074 Tübingen, Germany.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Contrast enhancement of surface layers with fast middle-infrared scanning
Journal: Heliyon, doi: 10.1016/j.heliyon.2019.e02442
T. Kümmel1,3, T. Teumer1,2, P. Dörnhofer1, F.-J. Methner2, B. Wängler3, M. Rädle1
1Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, Mannheim, 68163, Germany
2Institute of Food Technology and Food Chemistry, Technische Universität Berlin, Seestraße 13, Berlin, 13353, Germany
3University of Heidelberg, Medical Faculty Mannheim, Theodor-Kutzer-Ufer 1-3, Mannheim, 68167, Germany
Model-based Scale-up Predictions: From Microto Millireactors using Inline FT-IR Spectroscopy
Journal: Organic Process Research & Development, doi.org/10.1021/acs.oprd.9b00265
V. Fath1,2,*, St. Szmais3, P. Lau3, N. Kockmann1, T. Röder2
1Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Str. 70, 44227 Dortmund, Germany
2Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
3Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Investigation of local layer thickness distributions in fluids with the help of near-infrared image analysis
Journal: Chemie Ingenieur Technik, doi: 10.1002/cite.201800106
I. Medina1, L. Schmitt1, V. Kapoustina1, M. Rädle1, St. Scholl2
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences Paul-Wittsack Str. 10, 68163 Mannheim, Germany
2Technische Universita¨t Braunschweig, Institut für Chemische und Thermische Verfahrenstechnik, Langer Kamp 7, 38106 Braunschweig, Germany
Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors
Journal: Cell Chemical Biology, doi.org/10.1016/j.chembiol.2019.06.004
D. Weigt1,*, C. A.Parrish2, J. A.Krueger3, C. A.Oleykowski3, Al. R.Rendina4, C. Hopf1
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim Technical University, Paul-Wittsack-Strasse 10, 68163 Mannheim, Germany
2Medicinal Chemistry, GlaxoSmithKline, 1250 S Collegeville Road, Collegeville, PA 19426, USA
3Immuno-Oncology and Combinations Research Unit, GlaxoSmithKline, 1250 S Collegeville Road, Collegeville, PA 19426, USA
4Screening, Profiling and Mechanistic Biology, GlaxoSmithKline, 1250 S Collegeville Road, Collegeville, PA 19426, USA
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Data fusion of GC-IMS data and FT-MIR spectra for the authentication of olive oils and honeys—is it worth to go the extra mile?
Journal: Analytical and Bioanalytical Chemistry, doi: 10.1007/s00216-019-01978-w
S. Schwolow1, N. Gerhardt1, S. Rohn2, P. Weller1
1Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
2Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, 20146 Hamburg, Germany
The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH)
Journal: Frotiers in Physiology, doi.org/10.3389/fphys.2019.00770
S. Schwolow1, N. Gerhardt1, S. Rohn2, P. Weller1, H. K. Drescher1, R. Weiskirchen2, A. Fülöp3, C. Hopf3, E. González de San Román4, P. F. Huesgen4, A. de Bruin5, L. Bongiovanni5, A. Christ6,7, R. Tolba8, Ch. Trautwein1, D. C. Kroy1
1Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany
2Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital RWTH Aachen, Aachen, Germany
3Center for Biomedical Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany
4Central Institute for Engineering, Electronics and Analytics, ZEA-3 – Forschungszentrum Jülich, Jülich, Germany
5Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
6Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany
7Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States
8Institute of Laboratory Animal Science and Experimental Surgery and Central Laboratory for Laboratory Animal Science, University Hospital RWTH Aachen, Aachen, Germany
In Situ Reaction Monitoring of Unstable Lithiated Intermediates through Inline FTIR Spectroscopy
Journal: Chemical Engineering Technology, doi.org/10.1002/ceat.201900074
Verena Fath1,*, Prof. Dr. Norbert Kockmann2, Prof. Dr. Röder1
1Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Strasse 10, 68163 Mannheim, Germany.
2Department of Biochemical and Chemical Engineering, Equipment Design, TU Dortmund University, Emil-Figge-Strasse 70, 44227 Dortmund, Germany.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Fast local Raman measurement to investigate concentration profiles during mixing processes in microchannels
Journal: Chemie Ingenieur Technik, doi.org/10.1002/cite.201800105
J. Deuerling1,*, St. Manser1,*, J. Siber1,*, Sh. Keck1,*, Th. M. Hufnagel1,*, L. Schmitt1,*, I. Medina1,*, Prof. Dr. Matthias Rädle1, Prof. Dr.-Ing. Jens-Uwe Repke2
1Hochschule Mannheim, CeMOS – Center for Mass Spectrometry and Optical Spectroscopy, Paul-Wittsack-Straße 10, 68163 Mannheim, Deutschland.
2 Technische Universitaät Berlin, Fachgebiet Dynamik und Betrieb technischer Anlagen, Straße des 17. Juni 135, 10623 Berlin, Deutschland.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
A customized multispectral needle probe combined with a virtual photometric setup for in vivo detection of Lewis lung carcinoma in an animal model. Measurement Science and Technology
Journal: Measurement Science and Technology, doi.org/10.1088/1361-6501/ab24a1
F. Braun1,*, R. Schalk1,*, M. Nachtmann1,*, A. Hien1,*, R. Frank1,*, Th. Beuermann2, F.-J. Methner3, B. Kränzlin4, M. Rädle1,5, N. Gretz4,5
1Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
2Institute for Process Control, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
3Institute of Biotechnology, Technical University of Berlin, Chair of Brewing Science, Berlin, Germany
4Medical Research Center, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Lattice-Boltzmann Simulation and Experimental Validation of a Microfluidic T-Junction for Slug Flow Generation
Journal: Chemical Engineering, doi.org/10.3390/chemengineering3020048
V. Paul Schulz1, N. Abbaspour1, T. Baumeister2 , T. Röder2
1Department of Mechanical Engineering, Cooperative State University Mannheim, Coblitzallee 1-9, 68163 Mannheim
2Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany; t.baumeister@mail.de (T.B.)
A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells
Journal: BMC Cancer, doi: 10.1186/s12885-019-5606-4
J. Klicks1,2,*, C. Maßlo3, A. Kluth4, R. Rudolf1,2, M. Hafner1,2
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.
2Institute of Medical Technology, Mannheim University of Applied Sciences and Medical Faculty Mannheim of Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Quality assessment of olive oils based on temperature-ramped HS-GC-IMS and sensory evaluation: Comparison of different processing approaches by LDA, kNN, and SVM
Journal: Food Chemistry, doi: 10.1016/j.foodchem.2018.11.095
N. Gerhardt1, S. Schwolow1, S. Rohn2, P. RuizPérez-Cacho3, H. Galán-Soldevilla3, L. Arced4, P. Weller1
1Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2Institute of Food Chemistry, Hamburg School of Food Science, University of Hamburg, 20146 Hamburg, Germany
3Laboratorio de Estudios Sensoriales (GrupoSens), Departamento de Bromatología y Tecnología de los Alimentos, Universidad de Córdoba. Campus de Rabanales, 14070 Córdoba, Spain
4Department of Analytical Chemistry, Institute of Fine Chemistry and Nanochemistry, University of Córdoba, Campus de Rabanales, Marie Curie Annex Building, 14071 Córdoba, Spain
Influence of a single microstructure on local mass transfer in liquid film flows
Journal: Chemical Engineering Research and Design, doi: 10.1016/j.cherd.2019.04.022
V. Kapoustina1, J. Guffart1, A. Hien1, J. Strischakov1, I. Medina1, M. Rädle1, J. Repke2
1Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, Mannheim, Germany.
2Chair of Process Dynamics and Operation, Technische Universität Berlin, Berlin, Germany.
A Novel Optical Tissue Clearing Protocol for Mouse Skeletal Muscle to Visualize Endplates in Their Tissue Context.
Journal: Frontiers in Cellular Neuroscience, doi.org/10.3389/fncel.2019.00049
M. P. I. Williams1,*, M. Rigon1,*, T. Straka1,2,*, S. J. Hörner1,2,*, M. Thiel3, N. Gretz4,5, M. Hafner1,5, M. Reischl6, R. Rudolf1,2,5,7
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany
2Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany
3Department of Anesthesiology and Surgical Intensive Care Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
4Medical Faculty Mannheim, Medical Research Center, Heidelberg University, Mannheim, Germany
5Medical Faculty Mannheim, Institute of Medical Technology, Mannheim University of Applied Sciences, Mannheim, Germany
6Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
7Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Reactor Concept for Contactless Kinetic Measurement in Oscillating Droplets via Raman Spectroscopy
Journal: Chemie Ingenieur Technik, doi.org/10.1002/cite.201800199
T. Klement1,*, Prof. Dr. T. Röder1, Prof. Dr.-Ing. N. Kockmann2
1Mannheim University of Applied Sciences, Institute of Chemical Process Engineering, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany.
2TU Dortmund University, Faculty of Biochemical and Chemical Engineering, Laboratory of Equipment Design, Emil-FiggeStraße 70, 44227 Dortmund, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Bone Sialoprotein Shows Enhanced Expression in Early, High-Proliferation Stages of Three-Dimensional Spheroid Cell Cultures of Breast Cancer Cell Line MDA-MB-231.
Journal: Frontiers in Oncology, doi.org/10.3389/fonc.2019.00036
V. Rustamov1,2,*, F. Keller1,2,*, J. Klicks1,2,*, M. Hafner1,2, R. Rudolf1,2
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany
2Institute of Medical Technology of Heidelberg University and Mannheim University of Applied Sciences, Mannheim, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development
Journal: Current Opinion in Biotechnolgy, doi: 10.1016/j.copbio.2018.08.003
S. Schulz1, M. Becker2, M.R. Groseclose3, S. Schadt4, C. Hopf1
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany.
2Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach/Riss, Germany.
3Bioimaging US, GlaxoSmithKline, King of Prussia, PA 19406, United States.
4Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
Model-based scale-up and reactor design for solvent-free synthesis of an ionic liquid in a millistructured flow reactor
Journal: Reaction Chemistry & Engineering, doi: 10.1039/c8re00148k
S. Schwolow1,*, B. Mutsch1,*, N. Kockmann2, T. Röder1
1Mannheim University of Applied Sciences, Institute of Chemical Process Engineering, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany
2TU Dortmund University, Biochemical and Chemical Engineering, Equipment Design, Emil-Figge-Straße 68, 44227 Dortmund, Germany
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
A cationic near infrared fluorescent agent and ethyl-cinnamate tissue clearing protocol for vascular staining and imaging
Journal: Scientific Reports, doi: 10.1038/s41598-018-36741-1
J. Huang1,2, C. Brenna1,2, A.U. Khan1,2, C. Daniele1,2, R. Rudolf2,3, V. Heuveline4, N. Gretz1,2
1Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
2Institute for Medical Technology, University of Heidelberg and University of Applied Sciences, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
3Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163, Mannheim, Germany.
4Director of the Computing Centre, Heidelberg University, Im Neuenheimer Feld 293, 69120, Heidelberg, Germany.
Year 2018
Development of a particle measuring system for recording the scattered light intensities, optimized for the use of very weak laser beams
Journal: Chemie Ingenieur Technik, doi: https://doi.org/10.1002/cite.201800073
T. Teumer1, T. Hufnagel1,,*, T. Schäfer1, R. Schlarp‐Horvath1, H.P. Karbstein2, F.J. Methner3, M. Rädle1
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
1Hochschule Mannheim, CeMOS – Center of mass spectrometry and optical spectroscopy, Paul-Wittsack-Straße 10, 68163 Mannheim, Deutschland.
2KIT, Institut für Bio- und Lebensmitteltechnik, Teilinstitut I: Lebensmittelverfahrenstechnik, Kaiserstraße 12, 76131 Karlsruhe, Deutschland.
3Technische Universita¨t Berlin, Institut für Lebensmitteltechnologie und Lebensmittelchemie, Fachgebiet Brauwesen, Straße des 17. Juni 135, 10623 Berlin, Deutschland.
Site-to-Site Reproducibility and Spatial Resolution in MALDI-MSI of Peptides from Formalin-Fixed Paraffin-Embedded Samples
Journal: Proteomics Clinical Applications, doi: https://doi.org/10.1002/prca.201800180
A. Ly5, R. Longuespée6, R. Casadonte1, P. Wandernoth1, K. Schwamborn2, Ch. Bollwein2, Ch. Marsching3, K. Kriegsmann4, C. Hopf3, W. Weichert2, J. Kiregsmann1, P. Schirmacher6, M. Kriegsmann6, S.-O. Deininger5
1Proteopath GmbH, Trier, Germany.
2Institute of Pathology Technical University of Munich Munich, Germany.
3Center for Biomedical Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany.
4Department of Hematology Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
5Bruker Daltonik GmbH, Bremen, Germany.
6Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
A customized stand-alone photometric Raman sensor applicable in explosive atmospheres: a proof-of-concept study
Journal: Journal of Sensor and Sensor Systems, doi.org/10.5194/jsss-7-543-2018
M. Nachtmann1, S.P. Keck1,*, F. Braun1, H. S. Eckhardt2, Chr. Mattolat2, N. Gretz3, St. Scholl4, M. Rädle1
1Institute for Process Control and Innovative Energy Conversion, Mannheim University of Applied Sciences, Mannheim, 68163, Germany.
2tec5 AG, Oberursel/Ts, 61440, Germany.
3Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
4Institute for Chemical and Thermal Process Engineering, Technical University Braunschweig, Braunschweig, 38106, Germany.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development.
Journal: Current Opinion in Biotechnology, doi: https://doi.org/10.1016/j.copbio.2018.08.003
S. Schulz1, M. Becker2, M. Reid Groseclose3, S. Schadt4, C. Hopf1
1Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany
2Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach/Riss, Germany
3Bioimaging US, GlaxoSmithKline, King of Prussia, PA 19406, United States
4Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland
Automated analysis of lipid drug-response markers by combined fast and high-resolution whole cell MALDI mass spectrometry biotyping.
Journal: Scienetific Reports, doi.org/10.1038/s41598-018-29677-z
D. Weigt1,2, D. A. Sammour1, T. Ulrich1, B. Munteanu1, C. Hopf1,2
1Center for biomedical Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.
2HBIGS International Graduate School of Molecular and Cellular Biology, Heidelberg University, Im Neuenheimer Feld 501, 69120, Heidelberg, Germany.
Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle
Journal: International Journal of Molecular Sciences, doi: 10.3390/ijms19071935
T. Straka1,2,3, V. Vita4, K. Prokshi1,2, S. J. Hörner1,2,*, M.M. Khan1,2,3, M. Pirazzini4, M.P.I. Williams1,M. Hafner1, T. Zaglia4,5,6, R. Rudolf1,2,3,7
1Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
2Interdisciplinary Center for Neurosciences, Heidelberg University, 69120 Heidelberg, Germany.
3Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany.
4Venetian Institute of Molecular Medicine, 35129 Padua, Italy.
5Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
6Department of Cardiac Thoracic and Vascular Sciences, University of Padua, 35128 Padua, Italy.
7Author to whom correspondence should be addressed.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer’s Disease
Journal: Frontiers in Molecular Neuroscience, doi: https://doi.org/10.3389/fnmol.2018.00206
S. Herzer1,2, C. Hagan1,3, J. von Gerichten1,4, V. Dieterle1,2, B. Munteanu5, R. Sandhoff1,4, C. Hopf5, V. Nordström1,2*
1Division of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.
2Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany.
3Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States.
4Lipid Pathobiochemistry Group, German Cancer Research Center, Heidelberg, Germany.
5Center for Mass Spectrometry (CeMOS), University of Heidelberg and Mannheim University of Applied Sciences, Mannheim, Germany.
Volatile-Compound Fingerprinting by Headspace-Gas-Chromatography Ion-Mobility Spectrometry (HS-GC-IMS) as a Benchtop Alternative to 1H NMR Profiling for Assessment of the Authenticity of Honey.
Journal: Analytical Chemistry, doi.org/10.1021/acs.analchem.7b03748
N. Gerhardt1, M. Birkenmeier1, S. Schwolow2, S. Rohn1, P. Weller1
1Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
2Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, 20146 Hamburg, Germany.
Year 2017
In vitro skin three-dimensional models and their applications
Journal: Journal of Cellular Biotechnology, doi: 10.3233/JCB-179004
J. Klicks1,*, E. von Molitor1,*, T. Ertongur-Fauth2, R. Rudolf 1,3, M. Hafner1,3
1Mannheim University of Applied Sciences, Institute of Molecular and Cell Biology, Mannheim, Germany.
2BRAIN AG, Zwingenberg, Germany c Institute of Medical Technology, Heidelberg University, Heidelberg, Germany.
3Institute of Medical Technology, Heidelberg University, Heidelberg, Germany.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Long-term 3D culture of the SCC4 cell line using three different culture methods and initial seeding densities.
Journal of Cellular Biotechnology, doi: 10.3233/JCB-179005
V. Rustamov1,2, R. Rudolf1,2, V. Yagublu3, H.-M.Kuhn1, M. Vitacolonna1, M. Hafner1,2
1Institute of Molecular and Cell Biology, Faculty of Biotechnology, Mannheim University of Applied Sciences, Mannheim, Germany.
2Institute of Medical Technology, Heidelberg University, Heidelberg, Germany.
2Department of General, Visceral, Vascular, and Thoracic Surgery, Frankfurt Hoechst Hospital, Frankfurt, Germany.
Refinement of a neuronal differentiation protocol predominantly yields human iPS cell-derived dopaminergic neurons for the investigation of neurodegenerative pathomechanisms in vitro.
Journal: Journal of Cellular Biotechnology, doi:10.3233/JCB-179007
Y, Martí2,1, E. Nürnberg3,1,*, S. Horschitz2, M. Hafner3, P. Schloss2, A. Meyer-Lindenberg2, T. Lau1
1Central Institute of Mental Health, Hector Institute for Translational Brain Research, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
2Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Department Psychiatry and Psychotherapy, Mannheim, Germany.
3Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, Mannheim, Germany.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany
Resolution-optimized headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS) for non-targeted olive oil profiling.
Journal: Analytical and Bioanalytical Chemistry, doi.org/10.1007/s00216-017-0338-2
N. Gerhardt1, M. Birkenmeier1, D. Sanders2, S. Rohn3, P. Weller1
1Institute for Instrumental Analytics and Bioanalysis, Mannheim University of Applied Sciences, Paul-Wittsack-Strasse 10, 68163 Mannheim, Germany.
2Gesellschaft für Analytische Sensorsysteme mbH, Otto-Hahn-Straße 15, 44227 Dortmund, Germany 3 Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies
Journal: Scientific Reports, doi: 10.1038/s41598-017-18477-6.
J.-H. Rabe1,2, D.A. Sammour1,2, S. Schulz1,2, B. Munteanu1,2, M. Ott3, K. Ochs3,6, P. Hohenberger4, A. Marx4, M. Platten3,4, Chr.A. Opitz5,6, D.S. Ory7, C. Hopf1,2
1Center for Applied Research in Applied Biomedical Mass Spectrometry (ABIMAS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.
2Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163, Mannheim, Germany.
3German Cancer Consortium (DKTK) CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
4University Medical Center Mannheim of Heidelberg University, Mannheim, Germany.
5Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
6Department of Neurology and National Center of Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
7Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, 63110, USA. Correspondence.
*M2Aind-PhD Student, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim/Germany.