SM²all Symposium

Microreactors and continuous synthesis, online spectroscopy process analytics

When: Monday, 24.6.19 from 9.00 clock and Tuesday, 25.6.2019 from 9.00 to 17.30 clock
Where: Mannheim University of Applied Sciences

We invite you to come to our event SM²all Symposium on Monday, 24.6.19 and on Tuesday, 25.6.2019 at the University of Applied Sciences Mannheim, to participate in workshops and a city tour followed by dinner on TAG 1 and on TAG 2 news from our BMBF research project and process chemistry.

Day 1

Workshops for further education, Monday, 24.6.2019 - University of Applied Sciences Mannheim

1st Workshop: Ultrahigh Resolution FT-ICR Mass Spectrometry, Prof. dr. Carsten Hopf - time follows.

2nd Workshop: Process Fundamentals of Microreactorn, Prof. Dr. med. Thorsten Röder - Time follows.

3rd Workshop: Multivariate data analysis of spectral data using R and ChemoSpec, Prof. Dr. Philipp Weller - time follows.

Participation fee per workshop is 200 Euro. M²Aind members receive a discount of 50 euros. The workshops are subject to reservation (4 minimum participants).

City tour followed by dinner, 16.00 - 18.00 clock
In the late afternoon, a city tour through Mannheim awaits you. It is an excursion into the world of famous pioneers and their inventions. After that we will have dinner together and let the evening fade away.

Day 2

Event SM²all Symposium, Tuesday, 25.6.2019 - 9.00 am to 5.30 pm - Mannheim University of Applied Sciences - Karl Völker Hall - Building A - Speyerer Str. 2-4 - 68163 Mannheim

You can expect exciting lectures and news from process development and process analysis. Here you will hear news from our projects. Companies from the industry are given the opportunity to report on current developments. All representatives of chemical process development are welcome. We look forward to many lectures. Here you can find the agenda.

The participation fee of 100 Euro includes participation in the SM²all Symposium (25.6.19) and city tour (24.6.19) without workshops. For M²Aind members, participation in the SM²all symposium and city tour is free of charge.

Please register here.

Mass Spectrometry and Surface Plasmon Resonance (SPR) Innovations in Pharma

Join several industry leaders from top pharma companies and academia around the globe as they present their  perspectives on using advanced MS and SPR based  technologies to streamline the drug development process. From lead generation all  the way through to pre-clinical assessment, Bruker has built on years of excellence in Mass Spectrometry to impact the pharmacological  related industry far beyond the traditional role of quantitation and process monitoring.


Seminar sessions
March 18, 2019 // 9.30 am - 6.30 pm
rapifleX MALDI Pharma Pulse, timsTOF Pro (trapped ion mobility) and SPR-32 (surface plasmon resonance) applications in Pharma
March 19, 2019 // 9 am - 4 pm
MS Imaging Applications in Pharma

Get more information here.

5. M²Aind Talk, Tuesday, 19. February 2019, 4.00 to 7.00 pm

We are pleased that the M²Aind Talk will take place outside the Hochschule Mannheim for the first time and that we will be guests at the IHK Rhein-Neckar in Heidelberg. We would like to thank the IHK Rhein-Neckar for their support and hospitality.

Based on the impulse project SM²all the three lectures of this M²Aind Talk will deal with the topic of chemical analysis with ion mobility spectrometry and drug testing in assays.

4.00 pm            Reception
4.30 pm            Welcome
4.40 pm            Lectures:

GC-IMS – Selective trace gas analysis of volatile compounds in industrial applications
Thomas Wortelmann, G.A.S. Gesellschaft für analytische Sensorsysteme mbH
Approaches to the quantification of terpenes from complex mixtures using two-dimensional GC-IMS and MCR-ALS
Prof. Dr. Philipp Weller / Rebecca Brendel, Innovation Partnership M²Aind M²Aind
Discovery of potent inhibitors of the hepatic & intestinal drug transporter OATP2B1 through a cell based fluorescence assay
Melissa Unger, Innovation Partnership M²Aind

5.30 pm            Networking (Fingerfood and drinks)
7.00 pm            End of the event

Please register until 10. February 2019 at the following e-mail address:
IHK Rhein-Neckar
Theodor Frey Saal
Hans-Böckler-Straße 4
69115 Heidelberg

Please note that the IHK Rhein-Neckar does not offer parking. But there are numerous car parks nearby. The IHK Rhein-Neckar is also easy to reach by public transport. You can find a map here.

Parkhaus Poststraße, Poststraße 7-9, 69115 Heidelberg
Parkhaus Bauhaus, Bahnhofstraße 4, 69115 Heidelberg
Parkhaus Europäischer Hof, Friedrich-Ebert-Anlage 1, 69117 Heidelberg

Public transport:
You can reach us by public transport: Stop Bismarckplatz

Three awards for the Innovation Partnership M²Aind in the competition „Ideenwettbewerb Biotechnologie“

Since 2016, the University of Applied Sciences Mannheim has been one of the ten Universities of Applied Sciences awarded by the Federal Ministry of Research for special research excellence with the so-called FH Impulse Innovation Partnership M²Aind "Multimodal Analytics and Intelligent Sensorics for the Healthcare Industry".

The university of Applied Sciences was able to prevail in a fierce competition and achieve funding from Berlin in the amount of initially € 5 million and an additional € 1.3 million from the industry. Three partners of the innovation partnership from the impulse project "SM²all" are among the recipients of the nationwide biotechnology competition, they convinced the external jury with their three submitted project proposals.

With this idea competition, the Ministry of Science and Art of Baden-Württemberg wants to promote research approaches that are characterized by original new solution strategies with a high scientific-technical success and development risk and are not associated with pure basic research or market-related research. Each of the winners of the competition will initially receive a grant of up to € 60,000 to conduct a nine-month feasibility study.

"We are very happy about this triple award", says Prof. Dr. Thorsten Röder, head of SM²all, who, together with Prof. Philipp Weller, was given the opportunity to prepare a feasibility study by the middle of this year. "These grants make it clear once again how high the creative capability of our innovation partnership is", emphasizes Prof. Dr. med. Carsten Hopf, Partner spokesman of M²Aind and head of the competence center CeMOS at the University of Mannheim. In the future, the CeMOS competence center will develop new evaluation techniques for microarrays together with the Karlsruhe Institute of Technology in the two other funded projects in order to advance key technology advances in efficiency enhancement, automation and cost reduction.

The aim of the impulse project SM²all is the modernization of the entire process chain of pharmaceutical production for small molecules and biopharmaceuticals.The main goal is to use an innovative combination of automation technology and online analysis to produce active ingredients in a continuously secured process and to test their function in order to increase patient safety and reduce manufacturing costs.


4. M²Aind Talk

On 11. December 2018, the Innovation Partnership M²Aind held their 4th M²Aind Talk. The main topic was Design Thinking and Entrepreneurship


Welcome: Prof. Dr. Carsten Hopf, M²Aind partnership spokesman, Hochschule Mannheim-University of Applied Sciences
Prof. Kirstin Kohler, Hochschule Mannheim-University of Applied Sciences and Tobias Etter, Roche Diabetes Care Deutschland GmbH: Creative problem solving in the digital health world / Different perspectives - a common goal
Prof. Dr. Karin Arregui, Hochschule Mannheim-University of Applied Sciences, Key Qualification Entrepreneurship: exploitation of inventions and scientific results

M²Aind Retreat 2018

[Translate to English:] M²Aind Retreat 2018
Ebernburg, Bad Kreuznach

From 15. to 16. October 2018 the M²Aind Retreat took place for the first time, in which industrial partners from the health sector and members of the Mannheim University of Applied Sciences participated.

The conference took place at the Ebernburg  in the Bad Kreuznach district of Bad Münster am Stein. In good weather, 52 participants took the opportunity to get a deeper insight into the M²Aind projects, to get to know the M²Aind team and the other project partners.

The first day started in the afternoon with a greeting from M²Aind partner spokesman Professor Dr. Carsten Hopf, who warmly welcomed the participants to the first M2Aind Retreat. An essential part of the agenda was the presentation of the impulse projects SM2all, M²OGA and M²edTech, which were described in detail by the project leaders Professor Dr. Thorsten Röder (SM²all), Professor Dr. Rüdiger Rudolf (M²OGA) and Professor Dr. Matthias Rädle (M²edTech) were presented.

Company presentations took place in the second part of the day. The aim was to find out more about our industrial partners and their project work and to find points of contact for possible cooperation in the future. We thank Dr. Katharina Cuk, BioNTech AG, Dr. Jens Fuchser, Bruker Daltonics GmbH, Dr. Dennis Reibel, Freudenberg Technology Innovation SE & Co KG, Dr. Anne Arnold, Immunodiagnostics AG, Mrs. Stefanie Szmais & Dr. Richard Schneider, Merck KGaA, Dr. Marcus Götz, MRC Systems GmbH, Professor Dr. Rolf-Jürgen Ahlers, ProxiVision GmbH, Dr. Vanya Todorova, Roche Diabetes Care GmbH, Dr. Norbert-Karl Egger, Sanofi-Aventis Germany GmbH, Dr. Friedrich Reinhard, GSK GmbH for their successful short pitches.

After the group special, a guided tour of the Ebernburg or a tour through the city of Bad Münster am Stein, the participants returned to the evening in the Ebernburgschänke. In a poster session, our project team presented their results to date in cooperation with their project partners. The project work and the exchange of all involved were the main focus of the evening. Everyone involved uses the opportunity to get to know each other better and to exchange ideas with other M²Aind partners across projects.

On the second day the poster session of the first day in the Ebernburgschänke was continued. This was followed by a review of the first day of the conference. At this point, we would like to thank our guest spokeswoman, Dr. Vanaya Todorova (Roche Diabetes Care GmbH) for a summary of the key points of the first day of the conference. It continued with the podium discussion conducted by Professor Dr. Mathias Hafner was moderated. We thank Dr. Jens Fuchser, Bruker Daltonics GmbH, Dr. Siegfried Bialoyan, Ernst & Young GmbH and Dr. Norbert-Karl Egger, Sanofi-Aventis Germany GmbH for a succinct review of the previous cooperation.

In the second part of the day, Professor Dr. Thorsten Röder an amusing online quiz, which the participants obviously liked. Subsequently, "Vision for M²Aind" was discussed in groups in terms of expectations, wishes and visions for the future. In the most beautiful weather, the respective speakers presented their results in the courtyard of Ebernburg.

We would like to thank all participants for the productive conference and look forward to the Retreat at the Ebernburg next year. We are very pleased about the good cooperation and the positive feedback on the event.

3. M²Aind Talk

On 11. December 2018, the Innovation Partnership M²Aind held their 3rd M²Aind Talk. The main topic was 3D-cell culture - technology and application

Welcome and introduction to the topic, Prof. Dr. Rüdiger Rudolf, Institute of Molecular and Cell Biology of the Hochschule Mannheim-University of Applied Sciences and Project Manager of the Impulse Project M²OGA
Foil-based 3D cell culture systems - a high-throughput / high-content, forward-looking technology, Eric Gottwald, 300 Microns
Novel 3D skin models for industrial research,, Torsten Ertongur-Fauth, BRAIN
3D models in drug discovery @ Merck, Onkologie, Richard Schneider & Julia Meier-Hubberten, Merck KGaA

Innovation Partnership M²Aind looks back on the successful "SM²all Mini Symposium" on "Chemical Process Development"

On 27. June 2018 the SM²all Mini Symposium Chemical Process Development took place for the first time at the University of Applied Sciences Mannheim. Well-known companies from the healthcare industry such as BASF, CHESS, Merck, Sanofi and GSK have participated with great interest. The focus of the symposium was the scientific work of the doctoral students, who dealt intensively with the aspects of the subproject SM²all Process Development and Process Analytics and presented them to the public with great success:

  • Verena Fath, Hochschule Mannheim-University of Applied Sciences, Autonomous Process Development and Kinetic Modeling
  • Clarissa Benzin, Hochschule Mannheim-University of Applied Sciences, Chloromethane as a methylating agent in a continuous reactor
  • Torsten Klement, Hochschule Mannheim-University of Applied Sciences, Contactless kinetics measurement in a drop reactor using Raman
  • Guest lecture: Dr. Christina Rau, GlaxoSmithKline GmbH, Characterization of the interactions of drug candidates with target proteins in complex matrices
  • Rebecca Brendel, Hochschule Mannheim-University of Applied Sciences, Analysis of terpenes using ion mobility spectrometry (IMS) in complex matrices
  • Thomas Hufnagel, Hochschule Mannheim-University of Applied Sciences, Investigation of crystallization in the drop reactor by means of high-resolution Raman spectroscopy

Many thanks to Dr. Christina Rau, Cellzome/GlaxoSmithKline GmbH, for her concise guest lecture. After the very positive feedback from the participants on the event, the SM²all Mini Symposium will take place annually.

Further information about the impulse project SM²all and the project team can be found under:

2. M²Aind Talk

On 17. April 2018, the innovation partnership M²Aind held the 2nd M²Aind Talk. It is a get-together of the health industry for the metropolitan area of ​​Rhein-Main-Neckar.

Three keynote lectures on "Process Development and Process Analytics" were held:
Welcome and introduction: Dr. Siegfried Bialojan, Ernst & Young GmbH
Stefan Bley, Ernst & Young GmbH, Industry 4.0 – Smart Production
Prof. Dr. Thorsten Röder, Hochschule Mannheim-University of Applied Sciences, Multiphase reaction in microreactors
Thomas Müller and Herr Ralf Stegemann, EM-Technik GmbH, Innovation in synthetic substance

We thank Ernst & Young GmbH for their kind support.

MALDI Innovations in Pharma 2018

In cooperation with Bruker Daltonik GmbH, the innovation partnership M²Aind held the congress "MALDI Innovations in Pharma 2018" from 21.-22. February 2018 at the Hochschule Mannheim-University of Applied Sciences. Over two days, around 120 industry and academia representatives from the pharmaceutical, chemical and biotechnology sectors took the opportunity to network and share the latest research findings. The focus of the event was, on the one hand, mark-free high-throughput screening methods using matrix-assisted laser desorption / ionization (MALDI) mass spectrometry as well as applications of MALDI-MS imaging in the pharmaceutical industry and chemical biology. There was a great deal of interest among the audience in the various areas of application presented by the speakers in 16 lectures.
The speakers came from research companies and institutions like:

Analytik Jena (Germany), AstraZeneca (UK), Boehringer Ingelheim (Germany), Bruker Daltonics (USA), Bruker Daltonik (Germany), CeMOS (Germany), GlaxoSmithKline (UK), GlaxoSmithKline (USA), ImaBiotech (France), Inserm (France), Merck KGaA (Germany), Newcastle University (UK), Roche Pharma (Switzerland), SCiLS GmbH (Germany)

Professor Carsten Hopf, initiator of the event and head of the Competence Center CeMOS - Center for Biomedical Mass Spectrometry and Optical Spectroscopy, invited interested parties to a tour of the BMBF and DFG funded Bruker Rhein-Neckar Center for MS Fingerprinting and Imaging. Professor Hopf looks back with satisfaction on a successful congress with international lectures: "There has never been such an international congress for MALDI mass spectrometry fully tailored to the interests of the pharmaceutical industry - screening assays on the one hand and imaging for DMPK and toxicology on the other hand. The great response documents the need for these technologies, and I am glad that Bruker has organized such an event with M2Aind. "

Vice-Rector for Research and Technology Transfer of the University of Mannheim, Professor Mathias Hafner, assesses the event as a complete success for the innovation partnership M²Aind: "Due to the great interest of the industry in this event, we feel confirmed that we have set the right priorities in research; we are internationally competitive here at the highest level."

BRAIN AG and HS Mannheim are developing 3D skin models for use in the health and cosmetics industry zur Anwendung in Gesundheits- und Kosmetikbranche

Research collaboration in the M²Aind Project for New High-Resolution, Real-Time 3D Skin Spheroids Screening Technologies
Mannheim University of Applied Sciences is building on expertise in the areas of 3D cell culture and state-of-the-art live cell imaging
BRAIN is contributing unique skin reporter cells, substance test libraries and market knowledge
Review article in the Journal of Cellular Biotechnology

The research project M²Aind (Multimodal Analytics and Intelligent Sensing for the Healthcare Industry) is a public-private partnership project under the leadership of the Mannheim University of Applied Sciences, which is funded by the Federal Ministry of Education and Research (BMBF) and was launched in January 2017. From the beginning BRAIN has been an active partner in the M²Aind network. Joint projects of BRAIN and Mannheim University of Applied Sciences include the development of a skin model in 3D to better understand the physiology of the skin with the aim of opening up new application possibilities in the health and cosmetics industry.
You can find the complete press release as PDF (German and English) here.

1. M²Aind Talk

In the news 2016/ Kick-Off 2017

April 2017, Press release from the Mannheim University of Applied Sciences
March 2017, Biospectrum
November 2016, Mannheim University
November 2016, MRN News
August 2016, Rhein Neckar newspaper
August 2016, Bioeconomy BW
August 2016, Business magazine Econo
August 2016, Press release from the Ministry of Science, Research and Art Baden-Württemberg
July 2016, Press release of the universities of applied sciences in Baden-Württemberg
July 2016, Mannheimer Morgen
July 2016, City of Mannheim Medical Technology Cluster
July 2016, Press release from the Mannheim University of Applied Sciences
July 1016, Press release from the BMBF
November 2015, Press release from the Mannheim University of Applied Sciences